Models of type 2 diabetes Journal Article
| Authors: | Somwar, R.; Fang, X.; Sweeney, G. |
| Article Title: | Models of type 2 diabetes |
| Abstract: | Type 2 diabetes is associated with many health complications making it imperative to understand the mechanisms responsible for insulin resistance. An epidemic prevalence has thrust obesity to the forefront as a major risk factor for type 2 diabetes and in this article we focus on recent attempts to develop models of obesity and diabetes. These models have provided new insights into the pathogenesis of insulin resistance in obesity and thus, enhance future potential for drug discovery. © 2005 Elsevier Ltd. All rights reserved. |
| Keywords: | carrier protein; unclassified drug; pathogenesis; anamnesis; nonhuman; drug targeting; pathophysiology; protein function; phenotype; disease association; heredity; obesity; drug design; risk factor; transgenic mouse; disease model; correlation analysis; insulin resistance; glucose homeostasis; insulin sensitivity; adiponectin; environmental factor; non insulin dependent diabetes mellitus; knockout mouse; hyperinsulinemia; fatty acid transport; fatty acid metabolism; fatty acid oxidation; glucose intolerance; fatty acid transport protein 1; fatty acid transport protein 4; malonyl coenzyme a; diabetogenesis; pancreas islet disease |
| Journal Title: | Drug Discovery Today: Disease Models |
| Volume: | 2 |
| Issue: | 3 |
| ISSN: | 1740-6757 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2005-01-01 |
| Start Page: | 183 |
| End Page: | 189 |
| Language: | English |
| DOI: | 10.1016/j.ddmod.2005.08.011 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 24 October 2012" - "Source: Scopus" |
