Disorders of glucose homeostasis in young adults treated with total body irradiation during childhood: A pilot study Journal Article


Authors: Chemaitilly, W.; Boulad, F.; Oeffinger, K. C.; Sklar, C. A.
Article Title: Disorders of glucose homeostasis in young adults treated with total body irradiation during childhood: A pilot study
Abstract: Impairment of glucose metabolism (in particular insulin resistance and type 2 diabetes mellitus) has been reported in patients who have undergone hematopoietic SCT (HSCT) during childhood, especially those treated with TBI. This pilot study was conducted to determine prevalence of and possible underlying mechanisms for impaired glucose homeostasis in young adults treated with HSCT and TBI and who were not previously known to have diabetes mellitus. A total of 10 subjects (6 males, 4 females) were evaluated. Mean ages were 13.0 ± 1.0 years at the time of TBI and 24.0 ± 1.1 years at the time of this study. Five subjects had laboratory evidence of insulin resistance using the homeostasis model assessment and the quantitative insulin sensitivity check index indices. Two of these subjects had impaired fasting glucose and four had decreased plasma insulin-like growth factor 1 levels. All 10 subjects had evidence of abdominal obesity. Insulin resistance is frequently observed in adult survivors of HSCT treated with TBI in childhood. Underlying mechanisms may include radiation-induced growth hormone deficiency and changes in body composition.
Keywords: adult; clinical article; acute granulocytic leukemia; cancer combination chemotherapy; drug megadose; laboratory diagnosis; protein blood level; etoposide; cyclophosphamide; thiotepa; growth hormone deficiency; whole body radiation; acute myeloblastic leukemia; allogeneic hematopoietic stem cell transplantation; insulin resistance; somatomedin c; abdominal obesity; acute lymphocytic leukemia; body composition; childhood; disorders of carbohydrate metabolism; glucose homeostasis; insulin sensitivity
Journal Title: Bone Marrow Transplantation
Volume: 44
Issue: 6
ISSN: 0268-3369
Publisher: Nature Publishing Group  
Date Published: 2009-09-01
Start Page: 339
End Page: 343
Language: English
DOI: 10.1038/bmt.2009.40
PROVIDER: scopus
PUBMED: 19308039
DOI/URL:
Notes: --- - "Cited By (since 1996): 2" - "Export Date: 30 November 2010" - "CODEN: BMTRE" - "Source: Scopus"
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MSK Authors
  1. Farid Boulad
    304 Boulad
  2. Charles A Sklar
    312 Sklar
  3. Kevin Oeffinger
    294 Oeffinger