Cancer/testis antigens, gametogenesis and cancer Journal Article
| Authors: | Simpson, A. J. G.; Caballero, O. L.; Jungbluth, A.; Chen, Y. T.; Old, L. J. |
| Article Title: | Cancer/testis antigens, gametogenesis and cancer |
| Abstract: | Cancer/testis (CT) antigens, of which more than 40 have now been identified, are encoded by genes that are normally expressed only in the human germ line, but are also expressed in various tumour types, including melanoma, and carcinomas of the bladder, lung and liver. These immunogenic proteins are being vigorously pursued as targets for therapeutic cancer vaccines. CT antigens are also being evaluated for their role in oncogenesis - recapitulation of portions of the germline gene-expression programme might contribute characteristic features to the neoplastic phenotype, including immortality, invasiveness, immune evasion, hypomethylation and metastatic capacity. |
| Keywords: | unclassified drug; methylation; clinical trial; review; nonhuman; neoplasms; antigen expression; cell proliferation; phenotype; spermatocyte; meiosis; unindexed drug; melanoma; metastasis; gene expression; protein protein interaction; cytotoxicity; tumor antigen; dna methylation; carcinogenesis; liver carcinoma; cancer invasion; chromosome aberration; germ line; transcription regulation; antigens, neoplasm; cancer vaccine; cpg island; cancer testis antigen; melanoma antigen 1; immunogenicity; recombinant antigen; tumor cell; tumor immunity; x chromosome; lung carcinoma; bladder carcinoma; aneuploidy; testis; germ-line mutation; trophoblast; spermatogenesis; cell immortalization; gametogenesis; spermatogonium; gamete; a disintegrin and metalloproteinase domain 2 antigen; b melanoma antigen; bromodomain testis specific antigen; brother of the regulator of imprinted sites antigen; chondrosarcoma associated gene 1 antigen; cutaneous t cell lymphoma associated antigen 1; down syndrome critical region gene 8 antigen; ferritin heavy polypeptide like 17 antigen; fetal and adult testis expressed 1 antigen; g antigen 1 antigen; interleukin 13 receptor alpha1; lactate dehydrogenase c antigen; lipase member 1 antigen; malignant melanoma associated protein 1 antigen; new york esophageal squamous cell carcinoma antigen 1; new york sarcoma 35 antigen; nuclear rna export factor 2 antigen; p antigen family member 5; sarcoma antigen 1; sperm associated with the nucleus antigen; sperm autoantigenic protein 17 antigen; synaptonemal complex protein 1 antigen; synovial sarcoma antigen; testes specific protease 50 antigen |
| Journal Title: | Nature Reviews Cancer |
| Volume: | 5 |
| Issue: | 8 |
| ISSN: | 1474-175X |
| Publisher: | Nature Publishing Group |
| Date Published: | 2005-08-01 |
| Start Page: | 615 |
| End Page: | 625 |
| Language: | English |
| DOI: | 10.1038/nrc1669 |
| PUBMED: | 16034368 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 414" - "Export Date: 24 October 2012" - "CODEN: NRCAC" - "Source: Scopus" |
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