Nomograms including nuclear matrix protein 22 for prediction of disease recurrence and progression in patients with Ta, T1 or CIS transitional cell carcinoma of the bladder Journal Article

  

Authors:	Shariat, S. F.; Zippe, C.; Lübecke, G.; Boman, H.; Sanchez Carbayo, M.; Casella, R.; Mian, C.; Friedrich, M. G.; Eissa, S.; Akaza, H.; Sawczuk, I.; Serretta, V.; Huland, H.; Hedelin, H.; Rupesh, R.; Miyanaga, N.; Sagalowsky, A. I.; Wians, F. Jr; Roehrborn, C. G.; Lotan, Y.; Perrotte, P.; Benayoun, S.; Marberger, M. J.; Karakiewicz, P. I.
Article Title:	Nomograms including nuclear matrix protein 22 for prediction of disease recurrence and progression in patients with Ta, T1 or CIS transitional cell carcinoma of the bladder
Abstract:	Purpose: We developed and validated nomograms that accurately predict disease recurrence and progression in patients with Ta, T1, or CIS transitional cell carcinoma (TCC) of the bladder using a large international cohort. Methods: Univariate and multivariate logistic regression models targeted histologically confirmed disease recurrence, and focused on 2,542 patients with bladder TCC from 10 participating centers. Variables consisted of pre-cystoscopy voided urine Nuclear Matrix Protein 22 (NMP22) assay, urine cytology, age and gender. Resulting nomograms were internally validated with bootstrapping. Nomogram performance was explored graphically with Loess smoothing plots. Results: Overall 957 patients had recurrent TCC. Tumor grade and stage was available for 898 patients, including 24% grade I, 43% grade II, and 33% grade III; 45% stage Ta, 32% T1 and/or CIS, and 23% T2 or greater. Bootstrap corrected predictive accuracy for any TCC recurrence was 0.842; grade III Ta/T1 or CIS was 0.869; and T2 or higher stage TCC of any grade was 0.858, Virtually perfect performance characteristics were observed for the nomograms predicting any TCC recurrence or grade III Ta/T1 or CIS. The nomogram predicting T2 or higher stage TCC overestimated the observed probability for predicted values greater than 45%. Conclusions: We developed and internally validated nomograms that incorporate urinary NMP22, cytology, age and gender to predict with high accuracy the probability of disease recurrence and progression in patients with Ta, T1, and/or CIS bladder TCC. These nomograms could provide a means for individualizing followup in patients with Ta, T1, CIS bladder TCC. Copyright © 2005 by American Urological Association.
Keywords:	adolescent; adult; controlled study; aged; aged, 80 and over; middle aged; human cell; major clinical study; histopathology; cancer recurrence; cancer growth; validation process; cancer staging; follow up; neoplasm staging; diagnostic accuracy; tumor markers, biological; nuclear matrix protein 22; prediction; urinary bladder neoplasms; nuclear proteins; probability; nomograms; disease progression; multivariate logistic regression analysis; multivariate analysis; bladder neoplasms; cystoscopy; urinalysis; carcinoma, transitional cell; bladder carcinoma; gender; transitional cell carcinoma; nomogram; sample size; micturition; urine cytology
Journal Title:	Journal of Urology
Volume:	173
Issue:	5
ISSN:	0022-5347
Publisher:	Elsevier Science, Inc.
Date Published:	2005-05-01
Start Page:	1518
End Page:	1525
Language:	English
DOI:	10.1097/01.ju.0000154696.48217.75
PUBMED:	15821471
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-20244362785&partnerID=40&md5=39a5923feed5db6d63db32ab0613236c
Notes:	--- - "Cited By (since 1996): 65" - "Export Date: 24 October 2012" - "CODEN: JOURA" - "Source: Scopus"

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