Urinary cytology and nuclear matrix protein 22 in the detection of bladder cancer recurrence other than transitional cell carcinoma Journal Article
| Authors: | Hutterer, G. C.; Karakiewicz, P. I.; Zippe, C.; Lüdecke, G.; Boman, H.; Sanchez Carbayo, M.; Casella, R.; Mian, C.; Friedrich, M. G.; Eissa, S.; Akaza, H.; Serretta, V.; Hedelin, H.; Rupesh, R.; Miyanaga, N.; Sagalowsky, A. I.; Perrotte, P.; Lotan, Y.; Marberger, M. J.; Shariat, S. F. |
| Article Title: | Urinary cytology and nuclear matrix protein 22 in the detection of bladder cancer recurrence other than transitional cell carcinoma |
| Abstract: | OBJECTIVE: To assess the value of nuclear matrix protein-22 (NMP22), compared with urinary cytology, in predicting the recurrence of bladder cancer that is not transitional cell carcinoma (non-TCC). PATIENTS AND METHODS: We tested the sensitivity, specificity and the predictive accuracy of NMP22 in the context of non-TCC bladder cancer recurrence, and compared it to the performance of urinary cytology. The study group comprised 2687 patients with history of non-muscle-invasive bladder cancer from 10 centres across four continents. RESULTS: The mean patient age was 64.8 years and 75.4% were men; of all patients, 513 (19.1%) had positive urinary cytology, 906 (33.7%) had a positive NMP22 test (≥10 units/mL) and 80 (3.0%) had non-TCC recurrence. Most of these, i.e. 60 (75%), were stage ≥T2. The sensitivity and specificity of urinary cytology were, respectively, 20.0% and 94.8%, vs 77.5% and 81.8% for NMP22 of ≥10 units/mL. The predictive accuracy of urinary cytology was 57.5%, vs 87.1% for NMP22 ≥ 10 units/mL. A combined model that included dichotomized NMP22 and urinary cytology was 85.3% accurate. CONCLUSION: The ability of a NMP22 level of ≥10 units/mL to predict non-TCC recurrence was better than that of urinary cytology, suggesting that NMP22 might have a role in the surveillance of patients at risk of non-TCC recurrence. © 2008 THE AUTHORS. |
| Keywords: | adolescent; adult; child; aged; aged, 80 and over; middle aged; retrospective studies; major clinical study; clinical trial; cancer recurrence; squamous cell carcinoma; carcinoma, squamous cell; cancer risk; cancer diagnosis; diagnostic accuracy; sensitivity and specificity; cohort studies; neoplasm recurrence, local; tumor markers, biological; risk factors; bladder cancer; nuclear matrix protein 22; prediction; urinary bladder neoplasms; nuclear proteins; diagnostic value; multicenter study; predictive validity; predictive value of tests; intermethod comparison; protein urine level; transitional cell carcinoma; disease recurrence; urine cytology; nmp22 |
| Journal Title: | BJU International |
| Volume: | 101 |
| Issue: | 5 |
| ISSN: | 1464-4096 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2008-03-01 |
| Start Page: | 561 |
| End Page: | 565 |
| Language: | English |
| DOI: | 10.1111/j.1464-410X.2007.07352.x |
| PUBMED: | 18257856 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 7" - "Export Date: 17 November 2011" - "CODEN: BJINF" - "Source: Scopus" |
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