Distal cT2N0 rectal cancer: Is there an alternative to abdominoperineal resection? Journal Article
| Authors: | Rengan, R.; Paty, P.; Wong, W. D.; Guillem, J.; Weiser, M.; Temple, L.; Saltz, L.; Minsky, B. D. |
| Article Title: | Distal cT2N0 rectal cancer: Is there an alternative to abdominoperineal resection? |
| Abstract: | Purpose: Patients with cT2N0 distal rectal cancer do not require adjuvant therapy. However, when a patient refuses an abdominoperineal resection (APR), is there an alternative? The purpose of this trial is to determine whether preoperative external-beam radiation therapy can increase the rate of sphincter preservation for patients with distal cT2N0 adenocarcinoma of the rectum. Patients and Methods: Between April 1988 and October 2003, 27 patients with distal rectal adenocarcinoma staged T2 by clinical and/or endorectal ultrasound who were judged by the operating surgeon to require an APR were treated with preoperative pelvic radiation alone (50.4 Gy). Surgery was performed 4 to 7 weeks later. If pathologic positive pelvic nodes were identified, postoperative adjuvant chemotherapy was recommended. The median follow-up was 55 months (range, 9 to 140 months). Results: The pathologic complete response rate was 15% and 78% of patients underwent a sphincter-sparing procedure. The crude incidence of local failure for patients undergoing a sphincter sparing procedure was 10% and the 5-year actuarial incidence was 13%. The actuarial 5-year survival for patients undergoing sphincter preservation was as follows: disease-free, 77%; colostomy-free, 100%; and overall, 85%. Using the Memorial Sloan-Kettering Cancer Center sphincter function score, 54% of those undergoing a sphincter-sparing procedure had good/excellent bowel function at 12 to 24 months after surgery, and 77% had good/excellent function at 24 to 36 months after surgery. Conclusion: Our data suggest that for patients with cT2N0 distal rectal cancer who require an APR, preoperative pelvic radiation improves sphincter preservation without an apparent compromise in local control or survival. © 2005 by American Society of Clinical Oncology. |
| Keywords: | adult; cancer chemotherapy; cancer survival; clinical article; controlled study; treatment outcome; aged; treatment failure; clinical trial; fluorouracil; cancer staging; follow up; bolus injection; controlled clinical trial; incidence; folinic acid; external beam radiotherapy; intestine function; rectum cancer; transrectal ultrasonography; rectum abdominoperineal resection; anus sphincter |
| Journal Title: | Journal of Clinical Oncology |
| Volume: | 23 |
| Issue: | 22 |
| ISSN: | 0732-183X |
| Publisher: | American Society of Clinical Oncology |
| Date Published: | 2005-08-01 |
| Start Page: | 4905 |
| End Page: | 4912 |
| Language: | English |
| DOI: | 10.1200/jco.2005.10.041 |
| PROVIDER: | scopus |
| PUBMED: | 16051945 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 26" - "Export Date: 24 October 2012" - "CODEN: JCOND" - "Source: Scopus" |
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