Intensity-modulated radiation therapy in head and neck cancers: Dosimetric advantages and update of clinical results Journal Article
| Authors: | Puri, D. R.; Chou, W.; Lee, N. |
| Article Title: | Intensity-modulated radiation therapy in head and neck cancers: Dosimetric advantages and update of clinical results |
| Abstract: | Intensity-modulated radiation therapy (IMRT) is an exciting new modality in radiation therapy. The head and neck region is an ideal target for this new technology for several reasons. First, IMRT offers the potential for improved tumor control through delivery of high doses to the target volume. Second, because of sharp dose gradients, IMRT results in the relative sparing of normal structures in the head and neck region. Third, organ motion is virtually absent in the head and neck region, so, with proper immobilization, treatment can be delivered accurately. Although this is a relatively new technology, preliminary studies show excellent dosimetric profiles and clinical results. Salivary gland sparing has also resulted in reduced incidence and severity of xerostomia. Early reports of improvement in tumor control with better side effect profiles versus conventional techniques are promising, but will need to be confirmed with longer follow-up. Copyright © 2005 by Lippincott Williams & Wilkins. |
| Keywords: | adult; treatment outcome; aged; aged, 80 and over; disease-free survival; middle aged; retrospective studies; clinical trial; review; intensity modulated radiation therapy; salvage therapy; carcinoma, squamous cell; cisplatin; fluorouracil; skin toxicity; paclitaxel; cancer radiotherapy; nuclear magnetic resonance imaging; follow up; follow-up studies; antineoplastic agent; lymphatic metastasis; neoplasm staging; carboplatin; quality of life; computer assisted tomography; neoplasm recurrence, local; tumor volume; mucosa inflammation; antineoplastic combined chemotherapy protocols; radiotherapy dosage; radiotherapy; incidence; computer; head and neck cancer; imrt; radiotherapy, intensity-modulated; dosimetry; xerostomia; platinum; salivary gland; thyroid cancer; nasopharynx cancer; dry eye; brain stem; osteoradionecrosis; lymphadenopathy; spinal cord lesion; oropharynx carcinoma; oropharyngeal neoplasms; hypopharyngeal neoplasms; tumor necrosis; pharyngitis |
| Journal Title: | American Journal of Clinical Oncology |
| Volume: | 28 |
| Issue: | 4 |
| ISSN: | 0277-3732 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2005-08-01 |
| Start Page: | 415 |
| End Page: | 423 |
| Language: | English |
| DOI: | 10.1097/01.coc.0000162443.08446.00 |
| PUBMED: | 16062086 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 23" - "Export Date: 24 October 2012" - "CODEN: AJCOD" - "Source: Scopus" |
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