Nasopharyngeal cancer Book Section
| Authors: | Tam, M. M.; Riaz, N.; Lee, N. Y. |
| Editors: | Nishimura, Y.; Komaki, R. |
| Article/Chapter Title: | Nasopharyngeal cancer |
| Abstract: | Intensity-modulated radiation therapy (IMRT) is now the standard of care in the treatment of nasopharyngeal carcinoma (NPC). NPC is a unique form of head and neck cancer given its proximity to several critical structures, and treatment primarily requires radiation therapy and chemotherapy. In this chapter, we explore clinical evidence in support of IMRT relative to conventional radiation therapy in terms of dosimetry and toxicity. We review how IMRT allows sparing of critical structures adjacent to NPC and specifically how parotid-sparing techniques have resulted in quality of life benefits for patients. Disease control outcomes with the use of IMRT have also been excellent. We also discuss the IMRT techniques established by Radiation Therapy Oncology Group and some differences in recommended doses and margins published by other institutions. The chapter concludes by reviewing exciting new directions regarding the use of radiation in NPC, the use of Epstein-Barr virus biomarkers and imaging predictors of outcomes, and potential forms of treatment intensification for high-risk NPC. © Springer Japan 2015. |
| Keywords: | imrt; radiation therapy; nasopharyngeal carcinoma |
| Book Title: | Intensity-Modulated Radiation Therapy: Clinical Evidence and Techniques |
| ISBN: | 978-4-431-55485-1 |
| Publisher: | Springer |
| Publication Place: | Tokyo, Japan |
| Date Published: | 2015-01-01 |
| Start Page: | 153 |
| End Page: | 170 |
| Language: | English |
| DOI: | 10.1007/978-4-431-55486-8_8 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book chapter: 8 -- Export Date: 2 November 2015 -- Source: Scopus |
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