Locally advanced thyroid cancer Journal Article
| Authors: | Patel, K. N.; Shaha, A. R. |
| Article Title: | Locally advanced thyroid cancer |
| Abstract: | Purpose of review: The purpose of this review is to summarize existing literature with respect to locally advanced thyroid cancer and define the intricacies of preoperative evaluation, surgical management of involved sites and postoperative treatment. Recent findings: Locally invasive thyroid cancer is an uncommon disease process, which carries significant morbidity and mortality. Current treatment modalities include appropriate surgery, radioactive iodine treatment and external beam radiation therapy. Proper evaluation of the extent of disease, with complete gross tumor removal, is paramount in managing this difficult problem. Surgical treatment is still the mainstay for locally advanced thyroid cancer. Summary: Little progress has been made in advancing the treatment of locally advanced thyroid cancer. Patient identification, evaluation and proper surgical management with adjuvant therapy, still remain the most effective course of treatment. Aggressive surgical treatment including removal of all gross tumor and still preserving vital structures along with adjuvant therapy is likely to offer the best results. There is a very high incidence of locoregional and distant failure in this group of patients. The understanding and recognition of histopathological variations, such as poorly differentiated thyroid cancer is also important. New molecular markers are needed to help identify and predict aggressive tumor behavior. © 2005 Lippincott Williams & Wilkins. |
| Keywords: | histone deacetylase inhibitor; histopathology; mortality; review; laryngectomy; vocal cord; adjuvant therapy; preoperative evaluation; neoplasm recurrence, local; morbidity; adenoma, oxyphilic; dyspnea; cancer invasion; molecular marker; dysphagia; patient care; antiinfective agent; radioactive iodine; positron-emission tomography; thyroidectomy; surgery; thyroid cancer; thyroid neoplasms; aspiration biopsy; esophagus; advanced; invasive; recurrent laryngeal nerve; trachea; carcinoma, papillary, follicular; hemoptysis; pharynx; muscle, skeletal; larynx cartilage; recurrent laryngeal nerve palsy; stridor; esophagus injury; aerodigestive tract; peroxisome proliferator activated receptor agonist |
| Journal Title: | Current Opinion in Otolaryngology & Head and Neck Surgery |
| Volume: | 13 |
| Issue: | 2 |
| ISSN: | 1068-9508 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2005-04-01 |
| Start Page: | 112 |
| End Page: | 116 |
| Language: | English |
| DOI: | 10.1097/01.moo.0000156161.82671.43 |
| PUBMED: | 15761287 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 17" - "Export Date: 24 October 2012" - "CODEN: COOSF" - "Source: Scopus" |
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