Human immunodeficiency virus type 1 (HIV)-1 Vpr-regulated cell death: Insights into mechanism Journal Article
| Authors: | Muthumani, K.; Choo, A. Y.; Premkumar, A.; Hwang, D. S.; Thieu, K. P.; Desai, B. M.; Weiner, D. B. |
| Article Title: | Human immunodeficiency virus type 1 (HIV)-1 Vpr-regulated cell death: Insights into mechanism |
| Abstract: | The destruction of CD4+ T cells and eventual induction of immunodeficiency is a hallmark of the human immunodeficiency virus type 1 infection (HIV-1). However, the mechanism of this destruction remains unresolved. Several auxiliary proteins have been proposed to play a role in this aspect of HIV pathogenesis including a 14 kDa protein named viral protein R (Vpr). Vpr has been implicated in the regulation of various cellular functions including apoptosis, cell cycle arrest, differentiation, and immune suppression. However, the mechanism(s) involved in Vpr-mediated apoptosis remains unresolved, and several proposed mechanisms for these effects are under investigation. In this review, we discuss the possibility that some of these proposed pathways might converge to modulate Vpr's behavior. Further, we also discuss caveats and future directions for investigation of the interesting biology of this HIV accessory gene. © 2005 Nature Publishing Group. All rights reserved. |
| Keywords: | signal transduction; pathogenesis; review; nonhuman; human immunodeficiency virus infection; protein function; t lymphocyte; animals; cell cycle; apoptosis; cell growth; protein interaction; cell differentiation; regulatory mechanism; carrier proteins; cd4-positive t-lymphocytes; cell cycle arrest; glucocorticoid; multiprotein complexes; virus replication; mitochondria; mitochondrion; peptide hydrolases; human immunodeficiency virus 1; hsp70 heat-shock proteins; eukaryotic initiation factors; hiv-1; receptors, glucocorticoid; intracellular membranes; heat shock protein; membrane potentials; cop9 signalosome; vpr protein; gene products, vpr; hiv-1 vpr; glucocorticoid receptor (gr); heat shock protein 70 (hsp70); mitochondrial membrane potential (mmp); nf-kappa b (nf-κb); membrane potential |
| Journal Title: | Cell Death and Differentiation |
| Volume: | 12 |
| Issue: | Suppl. 1 |
| ISSN: | 1350-9047 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2005-08-01 |
| Start Page: | 962 |
| End Page: | 970 |
| Language: | English |
| DOI: | 10.1038/sj.cdd.4401583 |
| PUBMED: | 15832179 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 30" - "Export Date: 24 October 2012" - "CODEN: CDDIE" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work