Targeting osseous metastases: Rationale and development of radio-immunotherapy for prostate cancer Journal Article
| Authors: | Morris, M. J.; Pandit-Taskar, N.; Divgi, C.; Larson, S.; Scher, H. I. |
| Article Title: | Targeting osseous metastases: Rationale and development of radio-immunotherapy for prostate cancer |
| Abstract: | For patients with metastatic prostate cancer, bone is the primary site of tumor localization and the major cause of disease-related morbidity and mortality. Hormonal therapy and chemotherapy alone cannot eradicate disease harbored in bone. The delivery of radiotherapy to the reservoir of disease is an approach previously only achievable using bone-seeking radiopharmaceuticals. Now, however, with the identification of tumor-specific targets, antibodies are being used to deliver radiotherapy to these sites. In this article, we review the rationale behind this approach, the targets being explored, the radiation sources available, and the antibodies currently under clinical development. |
| Keywords: | bone neoplasms; bone tumor; review; antineoplastic agents; methodology; antineoplastic agent; metabolism; metastasis; neoplasm proteins; pathology; radiation response; dose-response relationship, radiation; prostatic neoplasms; membrane antigen; immunology; membrane glycoproteins; prostate tumor; membrane protein; tumor protein; ligand; ligands; radioimmunotherapy; antibodies, neoplasm; glutamate carboxypeptidase ii; glutamate carboxypeptidase ii, human; antigens, surface; cancer antibody; psca protein, human |
| Journal Title: | Current Urology Reports |
| Volume: | 6 |
| Issue: | 3 |
| ISSN: | 1527-2737 |
| Publisher: | Springer |
| Date Published: | 2005-05-01 |
| Start Page: | 163 |
| End Page: | 170 |
| Language: | English |
| PUBMED: | 15869719 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 24 October 2012" - "Source: Scopus" |
Citation Impact
MSK Authors
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163Divgi -
577Morris -
342Pandit-Taskar -
958Larson -
1130Scher
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