Radionuclides as conditioning before stem cell transplantation Journal Article

  


Authors: Jurcic, J. G.; Scheinberg, D. A.
Article Title: Radionuclides as conditioning before stem cell transplantation
Abstract: Targeted radiotherapy using either radiolabeled monoclonal antibodies or bone-seeking radiopharmaceuticals can potentially result in delivery of high radiation doses to tumor or bone marrow with less toxicity to normal organs. High-dose radioimmunotherapy has produced encouraging results in lymphoma and leukemia. The use of alternative radionuclides and new combinations of radioimmunotherapy with chemotherapy may improve patient outcomes. Comparative trials will be necessary to confirm an improved therapeutic benefit with this approach.
Keywords: treatment outcome; acute granulocytic leukemia; radiation dose; combined modality therapy; antineoplastic combined chemotherapy protocols; stem cell transplantation; hematopoietic stem cell transplantation; monoclonal antibody; hematologic neoplasms; iodine 131; isotope labeling; lymphoma; radioisotope; radioimmunotherapy; clinical trials; alpha radiation; bismuth; actinium; yttrium 90; astatine 211; samarium 153; strontium 89; beta radiation; rhenium 186; humans; human; priority journal; article; holmium
Journal Title: Current Opinion in Hematology
Volume: 6
Issue: 6
ISSN: 1065-6251
Publisher: Lippincott Williams & Wilkins, Ltd.  
Date Published: 1999-11-01
Start Page: 371
End Page: 376
Language: English
DOI: 10.1097/00062752-199911000-00003
PUBMED: 10546789
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032694339&partnerID=40&md5=4f81eabec0ddad2832364bea9466b211
Notes: Article -- Export Date: 16 August 2016 -- Source: Scopus
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MSK Authors
  1. Joseph G Jurcic
    134 Jurcic
  2. David Scheinberg
    499 Scheinberg
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