Combination versus sequential single-agent therapy for the treatment of metastatic breast cancer Journal Article
| Authors: | Modi, S.; Seidman, A. |
| Article Title: | Combination versus sequential single-agent therapy for the treatment of metastatic breast cancer |
| Abstract: | The administration of combination versus single-agent chemotherapy for the treatment of metastatic breast cancer remains an unresolved and controversial issue. Previous randomised trials have shown that, while combinations offer higher objective response rates, they have not always improved time to progression, quality of life or overall survival. Rationally designed combination regimens incorporating new cytotoxic and biological agents have resulted in improved survival rates compared with monotherapy and only modest increases in toxicities. However, trials analysing combination therapies lack formal cross-over arms and do not allow comparison of these regimens with sequentially administered single-agent therapy. This paper presents the latest randomised data and reviews the advantages and disadvantages of these two approaches to the treatment of metastatic breast cancer. © 2005 Elsevier Ltd. All rights reserved. |
| Keywords: | prednisone; clinical trial; constipation; review; bevacizumab; cisplatin; doxorubicin; fluorouracil; cancer combination chemotherapy; hypertension; capecitabine; gemcitabine; paclitaxel; methotrexate; neurotoxicity; antineoplastic agent; metastasis; infection; breast cancer; anemia; bone marrow suppression; leukopenia; nausea; stomatitis; thrombocytopenia; vomiting; myalgia; peripheral neuropathy; combination chemotherapy; cyclophosphamide; vinblastine; docetaxel; arthralgia; asthenia; febrile neutropenia; gastrointestinal toxicity; systematic review; cardiotoxicity; mitoxantrone; sepsis; intermethod comparison; epirubicin; mitomycin c; trastuzumab; navelbine; mitomycin; hand foot syndrome; alopecia; proteinuria; meta analysis; hematologic disease; single agents |
| Journal Title: | EJC Supplements |
| Volume: | 3 |
| Issue: | 5 |
| ISSN: | 1359-6349 |
| Publisher: | Pergamon-Elsevier Science Ltd |
| Date Published: | 2005-12-01 |
| Start Page: | 3 |
| End Page: | 8 |
| Language: | English |
| DOI: | 10.1016/s1359-6349(05)82018-x |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 24 October 2012" - "CODEN: ESJUB" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work