Point: Combination versus single-agent chemotherapy: The argument for sequential single agents Journal Article
| Authors: | Conlin, A. K.; Seidman, A. D. |
| Article Title: | Point: Combination versus single-agent chemotherapy: The argument for sequential single agents |
| Abstract: | Metastatic breast cancer is a heterogeneous disease, and treatment decisions depend on several individualized patient and tumor characteristics. Although combination therapy often shows improved response rates in metastatic breast cancer, few studies have shown superiority in overall survival. The choice of combination versus sequential single-agent treatment, therefore, must consider many factors, with no one strategy right for all patients. This article reviews several important clinical trials that address this issue, and argues for single-agent sequential therapy for most patients with metastatic breast cancer. © Journal of the National Comprehensive Cancer Network. |
| Keywords: | cancer chemotherapy; cancer survival; treatment response; survival analysis; survival rate; prednisone; clinical trial; disease course; review; cisplatin; doxorubicin; fluorouracil; cancer growth; monotherapy; treatment planning; antineoplastic agents; capecitabine; gemcitabine; paclitaxel; chemotherapy; methotrexate; outcome assessment; multiple cycle treatment; breast cancer; drug administration schedule; randomized controlled trials as topic; combination chemotherapy; cyclophosphamide; breast neoplasms; vinblastine; docetaxel; systematic review; mitoxantrone; neoplasm metastasis; epirubicin; combination therapy; navelbine; mitomycin; breast metastasis; metastatic breast cancer; meta analysis; drug dose sequence; lonidamine; sequential analysis; sequential therapy; single agent |
| Journal Title: | Journal of the National Comprehensive Cancer Network |
| Volume: | 5 |
| Issue: | 8 |
| ISSN: | 1540-1405 |
| Publisher: | Harborside Press |
| Date Published: | 2007-09-01 |
| Start Page: | 668 |
| End Page: | 672 |
| Language: | English |
| PUBMED: | 17927924 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 17 November 2011" - "Source: Scopus" |
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