Diagnosis and treatment of atypical and anaplastic meningiomas: A review Journal Article
| Authors: | Modha, A.; Gutin, P. H. |
| Article Title: | Diagnosis and treatment of atypical and anaplastic meningiomas: A review |
| Abstract: | Atypical and anaplastic meningiomas are uncommon tumors with a poorer prognosis than benign meningiomas. We reviewed the current literature and attempted to integrate and summarize available information to determine a logical approach to these tumors. Both tumors are rare and are often integrated with benign meningiomas when treatments are evaluated. In addition, because there has not been one histopathological classification scheme for atypical and anaplastic meningiomas in the past, there are numerous inconsistencies in the literature. Malignant progression with accumulation of mutations in a benign meningioma can result in an atypical and/or anaplastic meningioma. Both tumors are difficult to manage and have high recurrence and poor survival rates. The extent of tumor resection and histologicaf grade are the key determinants for recurrence. In addition, metastases are unusual, but they do occur. We also review the evidence available that has resulted in the current World Health Organization classification. Radiation therapy can be used as an adjunctive treatment after both total and subtotal resection. In addition, the role of stereotactic radiosurgery is increasing, along with a possible role for brachytherapy. There are no effective chemotherapeutic agents available. A treatment algorithm is suggested. |
| Keywords: | immunohistochemistry; cancer chemotherapy; cancer survival; cancer surgery; unclassified drug; gene mutation; hydroxyurea; clinical trial; histopathology; review; intensity modulated radiation therapy; angiogenesis inhibitor; bevacizumab; doxorubicin; erlotinib; drug efficacy; cancer adjuvant therapy; cancer radiotherapy; nuclear magnetic resonance imaging; recurrence risk; brain neoplasms; magnetic resonance imaging; cancer incidence; cancer grading; imatinib; metastasis; prevalence; cyclophosphamide; vincristine; vascular endothelial growth factor receptor-2; algorithms; cancer genetics; algorithm; meningeal neoplasms; radiation dose fractionation; disease progression; radiosurgery; gefitinib; vandetanib; vatalanib; brachytherapy; nuclear magnetic resonance spectroscopy; stereotactic radiosurgery; meningioma; mifepristone; tumor growth; cancer classification; drug therapy; anaplasia; rare disease; stereotaxic surgery; 6 [4 (4 ethyl 1 piperazinylmethyl)phenyl] 4 (alpha methylbenzylamino) 7h pyrrolo[2,3 d]pyrimidine; beam therapy; anaplastic meningiomas; atypical meningiomas; imc 1c11; anaplastic meningioma; atypical meningioma |
| Journal Title: | Neurosurgery |
| Volume: | 57 |
| Issue: | 3 |
| ISSN: | 0148-396X |
| Publisher: | Wolters Kluwer |
| Date Published: | 2005-09-01 |
| Start Page: | 538 |
| End Page: | 549 |
| Language: | English |
| DOI: | 10.1227/01.neu.0000170980.47582.a5 |
| PUBMED: | 16145534 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 68" - "Export Date: 24 October 2012" - "CODEN: NRSRD" - "Source: Scopus" |
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