Spinal meningiomas, from biology to management - A literature review Review
| Authors: | Serratrice, N.; Lameche, I.; Attieh, C.; Chalah, M. A.; Faddoul, J.; Tarabay, B.; Bou-Nassif, R.; Ali, Y.; Mattar, J. G.; Nataf, F.; Ayache, S. S.; Abi Lahoud, G. N. |
| Review Title: | Spinal meningiomas, from biology to management - A literature review |
| Abstract: | Meningiomas arise from arachnoidal cap cells of the meninges, constituting the most common type of central nervous system tumors, and are considered benign tumors in most cases. Their incidence increases with age, and they mainly affect females, constituting 25-46% of primary spinal tumors. Spinal meningiomas could be detected incidentally or be unraveled by various neurological symptoms (e.g., back pain, sphincter dysfunction, sensorimotor deficits). The gold standard diagnostic modality for spinal meningiomas is Magnetic resonance imaging (MRI) which permits their classification into four categories based on their radiological appearance. According to the World Health Organization (WHO) classification, the majority of spinal meningiomas are grade 1. Nevertheless, they can be of higher grade (grades 2 and 3) with atypical or malignant histology and a more aggressive course. To date, surgery is the best treatment where the big majority of meningiomas can be cured. Advances in surgical techniques (ultrasonic dissection, microsurgery, intraoperative monitoring) increase the complete resection rate. Operated patients have a satisfactory prognosis, even in those with poor preoperative neurological status. Adjuvant therapy has a growing role in treating spinal meningiomas, mainly in the case of subtotal resection and tumor recurrence. The current paper reviews the fundamental epidemiological and clinical aspects of spinal meningiomas, their histological and genetic characteristics, and their management, including the various surgical novelties and techniques. Copyright © 2023 Serratrice, Lameche, Attieh, Chalah, Faddoul, Tarabay, Bou-Nassif, Ali, Mattar, Nataf, Ayache and Abi Lahoud. |
| Keywords: | cancer chemotherapy; gene mutation; genetic trait; clinical feature; review; intensity modulated radiation therapy; adjuvant therapy; nuclear magnetic resonance imaging; neurosurgery; quality of life; histology; central nervous system; depression; tumor recurrence; radiosurgery; mental disease; world health organization; anxiety; motor dysfunction; motor performance; stereotactic body radiation therapy; sex hormone; adjuvant radiotherapy; electroencephalogram; spinal cord injury; hormone substitution; spine surgery; minimally invasive procedure; quadriplegia; meningiomas; intracranial meningioma; paraplegia; neuromonitoring; intraoperative monitoring; human; stereotactic body radiation therapy (sbrt); somatosensory evoked potential; t2 weighted imaging; t1 weighted imaging; gross total resection (gtr); microsurgery (ms); minimally invasive (mis); spinal meningiomas; ultrasonic dissection; motor evoked potential; spinal meningioma |
| Journal Title: | Frontiers in Oncology |
| Volume: | 12 |
| ISSN: | 2234-943X |
| Publisher: | Frontiers Media S.A. |
| Date Published: | 2022-01-01 |
| Start Page: | 1084404 |
| Language: | English |
| DOI: | 10.3389/fonc.2022.1084404 |
| PROVIDER: | scopus |
| PMCID: | PMC9880047 |
| PUBMED: | 36713513 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 March 2023 -- Source: Scopus |
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