Genes that mediate breast cancer metastasis to lung Journal Article
| Authors: | Minn, A. J.; Gupta, G. P.; Siegel, P. M.; Bos, P. D.; Shu, W.; Giri, D. D.; Viale, A.; Olshen, A. B.; Gerald, W. L.; Massague, J. |
| Article Title: | Genes that mediate breast cancer metastasis to lung |
| Abstract: | By means of in vivo selection, transcriptomic analysis, functional verification and clinical validation, here we identify a set of genes that marks and mediates breast cancer metastasis to the lungs. Some of these genes serve dual functions, providing growth advantages both in the primary tumour and in the lung microenvironment. Others contribute to aggressive growth selectively in the lung. Many encode extracellular proteins and are of previously unknown relevance to cancer metastasis. |
| Keywords: | genetics; cancer growth; nonhuman; genetic analysis; reproducibility; proteins; reproducibility of results; disease association; metastasis; breast cancer; genes; gene expression profiling; lung neoplasms; vascular cell adhesion molecule 1; cell protein; genetic transcription; transcription, genetic; pathology; cell line, tumor; breast neoplasms; lung tumor; rna; gene expression regulation; lung metastasis; gene expression regulation, neoplastic; tumors; cyclooxygenase 2; nucleotide sequence; breast tumor; cancer cell; tumor cell line; lung; neoplasm metastasis; microenvironment; interstitial collagenase; rna, neoplasm; collagenase; marker gene; gelatinase a; osteonectin; growth kinetics; prostaglandin synthase; pulmonary diseases; cancer metastasis; dual functions |
| Journal Title: | Nature |
| Volume: | 436 |
| Issue: | 7050 |
| ISSN: | 0028-0836 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2005-07-28 |
| Start Page: | 518 |
| End Page: | 524 |
| Language: | English |
| DOI: | 10.1038/nature03799 |
| PUBMED: | 16049480 |
| PROVIDER: | scopus |
| PMCID: | PMC1283098 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 803" - "Export Date: 24 October 2012" - "CODEN: NATUA" - "Molecular Sequence Numbers: GENBANK: HS109225, HS115263, HS118400, HS185568, HS196384, HS255149, HS368256, HS388589, HS410900, HS421986, HS444471, HS9613;" - "Source: Scopus" |
