Role of nutrients in the development of neonatal immune response Journal Article
| Authors: | Cunningham Rundles, S.; Lin, H.; Ho-Lin, D.; Dnistrian, A.; Cassileth, B. R.; Perlman, J. M. |
| Article Title: | Role of nutrients in the development of neonatal immune response |
| Abstract: | Nutrients exert unique regulatory effects in the perinatal period that mold the developing immune system. The interactions of micronutrients and microbial and environmental antigens condition the post-birth maturation of the immune system, influencing reactions to allergens, fostering tolerance towards the emerging gastrointestinal flora and ingested antigens, and defining patterns of host defense against potential pathogens. The shared molecular structures that are present on microbes or certain plants, but not expressed by human cells, are recognized by neonatal innate immune receptors. Exposure to these activators in the environment through dietary intake in early life can modify the immune response to allergens and prime the adaptive immune response towards pathogens that express the corresponding molecular structures. © 2009 International Life Sciences Institute. |
| Keywords: | review; nonhuman; conference paper; pathophysiology; immune system; drug effect; growth, development and aging; immunology; infant, newborn; vitamin d; pathogens; newborn; iron; pregnancy; innate immunity; immunity, innate; vitamin d deficiency; alpha tocopherol; ascorbic acid; selenium; allergens; early life; micronutrients; beta glucan; retinol; zinc; trace element; adaptive immunity; alpha tocopherol deficiency; ascorbic acid deficiency; dietary intake; host resistance; intestine flora; iron deficiency; malnutrition; nutrient; perinatal development; retinol deficiency; selenium deficiency; zinc deficiency; gastrointestinal tract; infant nutrition; maternal nutrition; microbiology; infant nutritional physiological phenomena; prenatal nutritional physiological phenomena |
| Journal Title: | Nutrition Reviews |
| Volume: | 67 |
| Issue: | SUPPL. 2 |
| ISSN: | 0029-6643 |
| Publisher: | Oxford University Press |
| Date Published: | 2009-01-01 |
| Start Page: | S152 |
| End Page: | S163 |
| Language: | English |
| DOI: | 10.1111/j.1753-4887.2009.00236.x |
| PUBMED: | 19906219 |
| PROVIDER: | scopus |
| PMCID: | PMC4566995 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 30 November 2010" - "CODEN: NUREA" - "Source: Scopus" |
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