Smad transcription factors Journal Article
| Authors: | Massague, J.; Seoane, J.; Wotton, D. |
| Article Title: | Smad transcription factors |
| Abstract: | Smad transcription factors lie at the core of one of the most versatile cytokine signaling pathways in metazoan biology - the transforming growth factor-β (TGFβ) pathway. Recent progress has shed light into the processes of Smad activation and deactivation, nucleocytoplasmic dynamics, and assembly of transcriptional complexes. A rich repertoire of regulatory devices exerts control over each step of the Smad pathway. This knowledge is enabling work on more complex questions about the organization, integration, and modulation of Smad-dependent transcriptional programs. We are beginning to uncover self-enabled gene response cascades, graded Smad response mechanisms, and Smad-dependent synexpression groups. Our growing understanding of TGFβ signaling through the Smad pathway provides general principles for how animal cells translate complex inputs into concrete behavior. © 2005 by Cold Spring Harbor Laboratory Press. |
| Keywords: | signal transduction; protein phosphorylation; review; nonhuman; protein domain; protein motif; animals; gene targeting; signaling; smad protein; smad2 protein; smad3 protein; transforming growth factor beta; carboxy terminal sequence; protein protein interaction; transcription initiation; transcription factor; transcription, genetic; animalia; transcription factors; gene expression regulation; dna; transcription regulation; transcription; smad proteins; multiprotein complexes; drosophila melanogaster; protein dephosphorylation; receptor affinity; protein structure; dna binding; structure analysis; x ray crystallography; beta catenin; protein variant; chromatin structure; genetic selection; metazoa; protein synthesis regulation; gap junction; smad; beta chain; tgf-β; karyopherin beta; protein mad1; receptor intrinsic activity |
| Journal Title: | Genes and Development |
| Volume: | 19 |
| Issue: | 23 |
| ISSN: | 0890-9369 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 2005-12-01 |
| Start Page: | 2783 |
| End Page: | 2810 |
| Language: | English |
| DOI: | 10.1101/gad.1350705 |
| PUBMED: | 16322555 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 818" - "Export Date: 24 October 2012" - "CODEN: GEDEE" - "Source: Scopus" |
