A self-enabling TGFβ response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells Journal Article
| Authors: | Kang, Y.; Chen, C. R.; Massagué, J. |
| Article Title: | A self-enabling TGFβ response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells |
| Abstract: | Genome-wide transcriptional profiling of human epithelial cells revealed that repression of Id inhibitors of differentiation (Id1, Id2, and Id3) is a general feature of the TGFβ cytostatic program. Opposite responses of Id1 to TGFβ and the related factor BMP are dictated by the specific ability of the TGFβ mediator, Smad3, to activate expression of stress response factor ATF3 and then recruit this factor to the Id1 promoter. Thus, a Smad3-mediated primary gene response, ATF3 induction, enables Smad3 to participate in an ATF3-mediated, secondary gene response. As a common target of TGFβ/Smad signals and stress signals via p38 kinase, ATF3 additionally serves to channel synergy between these pathways in the response of epithelial cells to stress and injury. |
| Keywords: | signal transduction; unclassified drug; dna binding protein; human cell; promoter region; genetics; dna-binding proteins; nonhuman; protein domain; animal cell; animal; metabolism; animals; cells, cultured; inhibitor of differentiation 1; smad protein; smad3 protein; transforming growth factor beta; protein protein interaction; protein; transcription factor; gene function; animalia; transcription factors; gene expression regulation; transcription regulation; cell culture; transactivator protein; smad3 protein, human; smad proteins; epithelium cell; protein induction; epithelial cells; stress; protein structure, tertiary; trans-activators; inhibitor of differentiation protein 1; repressor protein; repressor proteins; protein tertiary structure; cyclic amp responsive element binding protein; cyclic amp response element-binding protein; synaptophysin; smad4 protein; regulator gene; promoter regions (genetics); genes, regulator; humans; human; article; id1 protein, human; activating transcription factor 3; smad4 protein, human |
| Journal Title: | Molecular Cell |
| Volume: | 11 |
| Issue: | 4 |
| ISSN: | 1097-2765 |
| Publisher: | Cell Press |
| Date Published: | 2003-04-01 |
| Start Page: | 915 |
| End Page: | 926 |
| Language: | English |
| DOI: | 10.1016/s1097-2765(03)00109-6 |
| PUBMED: | 12718878 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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