The TGFβ pathway in basic oncology Journal Article

  


Author: Massague, J.
Article Title: The TGFβ pathway in basic oncology
Abstract: The transforming growth factor-β (TGFβ) family is particularly prominent among growth factors controlling cell proliferation and differentiation, and fosters tissue growth and morphogenesis during embryogenesis in organisms as diverse as the nematode, fruit fly, and human. To elucidate the basis for the great diversity of TGFβ responses in different cell types, we delineated the pathway linking membrane TGFβ receptors to target genes. TGFβ assembles a receptor complex in which the type II receptor kinase phosphorylates and activates the type I receptor. This type I receptor phosphorylates and activates Smad transcription factors. A receptor-activated Smad complex enters the nucleus to find partners for the recognition and regulation (activation of repression) of specific genes. TGFβ signaling decreases CDK activity and causes the repression of several growth-promoting genes. The TGFβ pathway, when altered, plays an essential role in tumorigenesis and metastasis.
Keywords: protein phosphorylation; review; nonhuman; protein function; cell proliferation; gene targeting; cell cycle; complex formation; metastasis; inhibitor of differentiation 1; smad protein; smad2 protein; smad3 protein; transforming growth factor beta; protein assembly; transcription initiation; transcription factor; drosophila; embryo development; gene function; morphogenesis; cell differentiation; oncology; carcinogenesis; cell type; tumor suppressor gene; gene activation; myc protein; gene repression; tyrosine kinase receptor; transforming growth factor beta receptor; protein family; cyclins; cyclin dependent kinase; cell cycle regulation; transforming growth factor beta receptor 1; nematode; transforming growth factor beta receptor 2; cyclin dependent kinase inhibitor 1; smad; tgfΒ; protein p16ink4a; cdks
Journal Title: Anales de la Real Academia Nacional de Farmacia
Volume: 71
Issue: 3
ISSN: 1697-428X
Publisher: Real Academia Nacional de Farmacia  
Date Published: 2005-01-01
Start Page: 525
End Page: 534
Language: English
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-30744450483&partnerID=40&md5=426adacbcb6c8ea4f6ddce0cd9cf97e7
Notes: --- - "Export Date: 24 October 2012" - "CODEN: ARAFA" - "Source: Scopus"