Monoclonal versus polyclonal antibodies: Distinguishing characteristics, applications, and information resources Journal Article
| Authors: | Lipman, N. S.; Jackson, L. R.; Trudel, L. J.; Weis-Garcia, F. |
| Article Title: | Monoclonal versus polyclonal antibodies: Distinguishing characteristics, applications, and information resources |
| Abstract: | Antibodies are host proteins that comprise one of the principal effectors of the adaptive immune system. Their utility has been harnessed as they have been and continue to be used extensively as a diagnostic and research reagent. They are also becoming an important therapeutic tool in the clinician's armamentarium to treat disease. Antibodies are utilized for analysis, purification, and enrichment, and to mediate or modulate physiological responses. This overview of the structure and function of polyclonal and monoclonal antibodies describes features that distinguish one from the other. A limited review of their use as specific research, diagnostic, and therapeutic reagents and a list of printed and electronic resources that can be utilized to garner additional information on these topics are also included. |
| Keywords: | immunohistochemistry; unclassified drug; review; nonhuman; rituximab; positron emission tomography; ovary cancer; breast cancer; immunoglobulin; antineoplastic activity; enzyme linked immunosorbent assay; monoclonal antibody; colorectal carcinoma; lung small cell cancer; immunology; capromab pendetide in 111; antibodies, monoclonal; nonhodgkin lymphoma; immunotherapy; recombinant antibody; diagnostic value; quantitative analysis; immunoprecipitation; immunoblotting; antibody specificity; antibodies; trastuzumab; enzyme linked immunospot assay; x ray crystallography; radioimmunotherapy; fluorescence activated cell sorting; antibody; antibody production; crohn disease; immunoglobulins; qualitative analysis; indicators and reagents; immunization; snakebite; epitopes; monoclonal antibody b.72.3; infliximab; monoclonal; polyclonal antibody; immunoscintigraphy; polyclonal; arcitumomab; crofab; nofetumomab merpentan; oncoscint; snake venom; verluma; antibody directed enzyme prodrug therapy; antibody structure; antigen purification |
| Journal Title: | ILAR Journal |
| Volume: | 46 |
| Issue: | 3 |
| ISSN: | 1084-2020 |
| Publisher: | Oxford University Press |
| Date Published: | 2005-01-01 |
| Start Page: | 258 |
| End Page: | 267 |
| Language: | English |
| PUBMED: | 15953833 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 32" - "Export Date: 24 October 2012" - "CODEN: IJLOA" - "Source: Scopus" |
