Deregulated TGF-β signaling in leukemogenesis Journal Article
| Authors: | Lin, H. K.; Bergmann, S.; Pandolfi, P. P. |
| Article Title: | Deregulated TGF-β signaling in leukemogenesis |
| Abstract: | Cellular homeostasis is tightly controlled by the various pathways that regulate cell proliferation and cell death. Breaking this balance is often associated with cancer development. The transforming growth factor-β (TGF-β) pathway plays an important role in cellular homeostasis by regulating cell growth inhibition, cellular senescence, differentiation and apoptosis. Deregulated TGF-β signaling is known to be involved in a variety of human cancers, including those of the colon, pancreas, breast and prostate. While TGF-β is a potent negative regulator of hematopoiesis, the role of aberrant TGF-β signaling in leukemogenesis remains largely unknown. Recently, evidence demonstrating deregulated TGF-β signaling in leukemogenesis, particularly in acute promyelocytic leukemia (APL), has started to emerge. In this review, we summarize the current progress towards the understanding of the molecular mechanisms by which aberrant TGF-β signaling may participate in leukemogenesis. © 2005 Nature Publishing Group. All rights reserved. |
| Keywords: | signal transduction; protein expression; leukemia; review; nonhuman; pancreas cancer; protein function; metastasis; apoptosis; breast cancer; gene expression; cell growth; nuclear protein; transforming growth factor beta; neoplasm proteins; transcription factor; cell differentiation; physiology; transcription factors; stem cell; nuclear proteins; prostate cancer; leukemia, promyelocytic, acute; regulatory mechanism; colon cancer; leukemogenesis; tumor suppressor proteins; tumor protein; cell membrane; promyelocytic leukemia; hematopoietic stem cells; hematopoietic stem cell; tumor suppressor protein; cell aging; endosome; pml-rarα; lipid raft; membrane microdomains; endosomes; tgf-β; cpml; sara; smad2/3; pml protein, human |
| Journal Title: | Oncogene |
| Volume: | 24 |
| Issue: | 37 |
| ISSN: | 0950-9232 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2005-08-29 |
| Start Page: | 5693 |
| End Page: | 5700 |
| Language: | English |
| DOI: | 10.1038/sj.onc.1208923 |
| PUBMED: | 16123802 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 25" - "Export Date: 24 October 2012" - "CODEN: ONCNE" - "Source: Scopus" |
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