Multimodality therapy of local regional esophageal cancer Journal Article
| Author: | Kelsen, D. P. |
| Article Title: | Multimodality therapy of local regional esophageal cancer |
| Abstract: | Recent trials regarding the use of multimodality therapy for patients with cancers of the esophagus and gastroesophageal junction have not conclusively shown benefit. Regimens containing cisplatin and fluorouracil administered preoperatively appear to be tolerable and do not increase operative morbidity or mortality when compared with surgery alone. Yet clinical trials have not clearly shown that such regimens improve outcome as measured by survival. Likewise, trials of postoperative chemoradiation have not reported a significant improvement in median or overall survival. The reasons for the lack of clinical benefit from multimodality therapy are not completely understood, but improvements in systemic therapy will probably be necessary before disease-free or overall survival improves substantially. Some new single agents such as the taxanes (docetaxel or paclitaxel) and the camptothecan analog irinotecan have shown modest activity for palliative therapy. © 2005 Elsevier Inc. All rights reserved. |
| Keywords: | cancer survival; survival analysis; clinical trial; postoperative period; cisplatin; doxorubicin; fluorouracil; drug efficacy; multimodality cancer therapy; antineoplastic agents; conference paper; paclitaxel; combined modality therapy; neoadjuvant therapy; methotrexate; adenocarcinoma; etoposide; radiotherapy; morbidity; palliative therapy; cancer mortality; docetaxel; irinotecan; protein tyrosine kinase inhibitor; preoperative period; randomized controlled trials; folinic acid; mitomycin; esophagus cancer; stomach neoplasms; esophageal neoplasms; epidermal growth factor receptor kinase; esophagogastric junction; uft |
| Journal Title: | Seminars in Oncology |
| Volume: | 32 |
| Issue: | Suppl. 9 |
| ISSN: | 0093-7754 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2005-12-01 |
| Start Page: | S6 |
| End Page: | S10 |
| Language: | English |
| DOI: | 10.1053/j.seminoncol.2005.04.025 |
| PUBMED: | 16399422 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 7" - "Export Date: 24 October 2012" - "CODEN: SOLGA" - "Source: Scopus" |
