Emerging targeted therapies for breast cancer Journal Article
| Authors: | Johnson, M. L.; Seidman, A. D. |
| Article Title: | Emerging targeted therapies for breast cancer |
| Abstract: | Targeted therapies offer a new approach to breast cancer treatment. Rather than eliminating both malignant and normal cells nonspecifically, these so-called "rational" therapies exploit second messenger proteins, ligands, and receptors that are known to be upregulated in neoplastic cells, or are implicated in cancer metastasis. This review will highlight a number of these targets and the mechanisms that have been targeted in drug design. We will also describe recently completed and currently ongoing clinical trials investigating targeted therapies and their potential to augment standard breast cancer therapy. |
| Keywords: | cancer chemotherapy; treatment outcome; treatment response; unclassified drug; genetics; clinical trial; drug tolerability; review; bevacizumab; doxorubicin; erlotinib; cancer growth; hypertension; nonhuman; antineoplastic agents; capecitabine; gemcitabine; paclitaxel; methodology; antineoplastic agent; imatinib; carboplatin; controlled clinical trial; breast cancer; tumor volume; randomized controlled trial; cyclophosphamide; protein tyrosine kinase; angiogenesis; breast neoplasms; cetuximab; docetaxel; monoclonal antibody; antibodies, monoclonal; drug antagonism; celecoxib; thromboembolism; breast tumor; gefitinib; tamoxifen; dna fingerprinting; receptor protein-tyrosine kinases; taxane derivative; trastuzumab; navelbine; epistaxis; proteinuria; geldanamycin; pulmonary hypertension; prostaglandin synthase inhibitor; cyclooxygenase inhibitors; 17 n allylamino 17 demethoxy geldanamycin |
| Journal Title: | Oncology (Norwalk) |
| Volume: | 19 |
| Issue: | 5 |
| ISSN: | 0890-9091 |
| Publisher: | C M P Medica LLC * The Oncology Group |
| Date Published: | 2005-04-01 |
| Start Page: | 611 |
| End Page: | 618 |
| Language: | English |
| PUBMED: | 15945342 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 8" - "Export Date: 24 October 2012" - "CODEN: OCLGE" - "Source: Scopus" |
