The synthesis and preliminary biological evaluation of a novel steroid with neurotrophic activity: NGA0187 Journal Article
| Authors: | Hua, Z.; Carcache, D. A.; Tian, Y.; Li, Y. M.; Danishefsky, S. J. |
| Article Title: | The synthesis and preliminary biological evaluation of a novel steroid with neurotrophic activity: NGA0187 |
| Abstract: | A full account of the total synthesis of neurotrophic compound NGA0187 is provided. A key feature of the synthesis involved the direct selective oxidation of 6α,7β-diol to install the unusual 6,7-ketol moiety and stereoselective conjugate addition of vinyl cuprate to enone. A preliminary evaluation of its ability to stimulate the neurite outgrowth was also evaluated with PC12 cell. © 2005 American Chemical Society. |
| Keywords: | controlled study; unclassified drug; drug activity; nonhuman; cell proliferation; animal cell; animals; steroid; neurons; drug evaluation, preclinical; drug synthesis; structure-activity relationship; rat; models, molecular; crystallography, x-ray; lipids; rats; oxidation; vinyl derivative; reaction analysis; molecular conformation; synthesis (chemical); stereochemistry; stereoisomerism; catalyst activity; steroids; cell strain; triterpenes; nerve growth factor; addition reactions; pc12 cells; conjugate addition; alcohols; addition reaction; nga 0187; neurotrophic activity; catalyst selectivity; enomes; ketol |
| Journal Title: | Journal of Organic Chemistry |
| Volume: | 70 |
| Issue: | 24 |
| ISSN: | 0022-3263 |
| Publisher: | American Chemical Society |
| Date Published: | 2005-11-25 |
| Start Page: | 9849 |
| End Page: | 9856 |
| Language: | English |
| DOI: | 10.1021/jo051556d |
| PUBMED: | 16292815 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 15" - "Export Date: 24 October 2012" - "CODEN: JOCEA" - "Source: Scopus" |
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3Carcache -
9
Hua -
539Danishefsky -
132Li -
16
Tian
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