Celiac disease presenting as a paraneoplastic syndrome in a patient with synchronous endometrial and ovarian cancers Journal Article


Authors: Haddad, L.; Amsterdam, A.; Chi, D. S.
Article Title: Celiac disease presenting as a paraneoplastic syndrome in a patient with synchronous endometrial and ovarian cancers
Abstract: Objective. Celiac disease is characterized by gluten intolerance and commonly manifests with unexplained diarrhea, abdominal distention and weight loss. Infrequently, patients present with vague, non-specific symptoms which often delay diagnosis and treatment. Case. A 52-year-old female with a history of synchronous endometrial and ovarian cancers, previously treated with surgical resection, staging and pelvic irradiation, presented with progressive paresthesias in her extremities. Extent of disease work-up was unremarkable. Neurologic evaluation suggested celiac disease which was later proven by duodenal biopsy. Conclusion. The development of new or worsening neurologic symptoms in the cancer patient requires a thorough evaluation especially to exclude metastatic disease and/or paraneoplastic syndromes. Once neoplastic processes are excluded, celiac disease should be considered in the differential diagnosis of patients with unexplained neurologic dysfunction. © 2005 Elsevier Inc. All rights reserved.
Keywords: adult; human tissue; treatment outcome; middle aged; cancer surgery; paresthesia; case report; cancer patient; cancer radiotherapy; cancer staging; endometrial cancer; endometrium carcinoma; lymph node dissection; endometrial neoplasms; salpingooophorectomy; ovarian cancer; ovarian neoplasms; ovary cancer; diagnosis, differential; peripheral neuropathy; differential diagnosis; tumor biopsy; tramadol; ca 125 antigen; paraneoplastic syndrome; neoplasms, multiple primary; abdominal hysterectomy; burning sensation; neurologic examination; endometriosis; gabapentin; paraneoplastic neuropathy; amitriptyline; celiac disease; gluten free diet; paraneoplastic syndromes; menorrhagia; duodenum biopsy; paraneoplastic syndromes, nervous system; gluten
Journal Title: Gynecologic Oncology
Volume: 97
Issue: 2
ISSN: 0090-8258
Publisher: Elsevier Inc.  
Date Published: 2005-05-01
Start Page: 704
End Page: 706
Language: English
DOI: 10.1016/j.ygyno.2005.01.008
PUBMED: 15863187
PROVIDER: scopus
DOI/URL:
Notes: --- - "Export Date: 24 October 2012" - "CODEN: GYNOA" - "Source: Scopus"
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  1. Dennis S Chi
    566 Chi