Brain metastases: Epidemiology and pathophysiology Journal Article

  


Authors: Gavrilovic, I. T.; Posner, J. B.
Article Title: Brain metastases: Epidemiology and pathophysiology
Abstract: Metastases are the most common tumors of the central nervous system (CNS), but cancer databases are often incomplete leading to underestimation of the incidence of even symptomatic brain metastases. Brain imaging studies are not routinely performed on neurologically asymptomatic cancer patients and autopsy studies are outdated. Furthermore, while incidence rates for cancers are stable and mortality is decreasing due to earlier detection and better therapy, the incidence of brain metastases appears to be increasing. The pathophysiology of brain metastases is a complex multistage process, mediated by molecular mechanisms; from the primary organ, cancer cells must transform, grow and be transported to the CNS where they can lay dormant for various lengths of time before invading and growing further. Understanding the pathophysiology of brain metastases is of great importance, because it may lead to the development of more efficient therapies to combat brain tumor growth or to possibly make the CNS an undesirable environment for tumor progression. © Springer 2005.
Keywords: cancer chemotherapy; gene mutation; review; cancer growth; nonhuman; pathophysiology; brain neoplasms; colorectal cancer; melanoma; breast cancer; incidence; cancer screening; lung cancer; angiogenesis; data base; cancer mortality; cancer invasion; cancer inhibition; meningeal neoplasms; early diagnosis; cancer cell; blood brain barrier; brain metastasis; gene silencing; kidney cancer; epidemiology; malignant transformation; brain blood flow; brain metastases; central nervous system metastasis; cns metastases; extravasation; brain circulation; brain scintiscanning; incidence rates; intracranial metastases
Journal Title: Journal of Neuro-Oncology
Volume: 75
Issue: 1
ISSN: 0167-594X
Publisher: Springer  
Date Published: 2005-10-01
Start Page: 5
End Page: 14
Language: English
DOI: 10.1007/s11060-004-8093-6
PUBMED: 16215811
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-27644546807&partnerID=40&md5=fa79760bbeff9eab4bdf2c7b1f72fa1e
Notes: --- - "Cited By (since 1996): 115" - "Export Date: 24 October 2012" - "CODEN: JNODD" - "Source: Scopus"
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MSK Authors
  1. Igor T Gavrilovic
    73 Gavrilovic
  2. Jerome B Posner
    211 Posner
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