Colon cancer: Clinical practice guidelines in oncology Journal Article
| Authors: | Engstrom, P. F.; Benson, A. B. 3rd; Chen, Y. J.; Choti, M. A.; Dilawari, R. A.; Enke, C. A.; Fakih, M. G.; Fuchs, C.; Kiel, K.; Knol, J. A.; Leong, L. A.; Ludwig, K. A.; Martin, E. W. Jr; Rao, S.; Saif, M. W.; Saltz, L.; Skibber, J. M.; Venook, A. P.; Yeatman, T. J. |
| Article Title: | Colon cancer: Clinical practice guidelines in oncology |
| Abstract: | The NCCN Colon/Rectal/Anal Cancer Guidelines panel believes that a multidisciplinary approach is necessary for managing colorectal cancer. The panel endorses the concept that treating patients in a clinical trial has priority over standard or accepted therapy. The recommended surgical procedure for resectable colon cancer is an en bloc resection. For patients with stage 111 disease, 5-FU-based adjuvant therapy is recommended. A patient who has metastatic disease in the liver or lung should be considered for surgical resection if he or she is a candidate for surgery and if surgery can extend survival. Surgery should be followed by adjuvant chemotherapy. The panel advocates a conservative posttreatment surveillance program for colon carcinoma patients. Serial CEA determinations are appropriate if the patient is a candidate for aggressive surgical resection, should recurrence he detected. Abdominal and pelvic CT scans should be used only when there are clinical indications of possible recurrence. Patients whose disease progresses during 5-FU-based therapy should be treated with combination chemotherapy consisting of 5-FU/leucovorin and either irinotecan or oxaliplatin. © Journal of the National Comprehensive Cancer Network. |
| Keywords: | cancer chemotherapy; cancer surgery; clinical feature; clinical trial; histopathology; review; cancer localization; cancer recurrence; salvage therapy; bevacizumab; fluorouracil; dose response; treatment planning; liver neoplasms; capecitabine; cancer adjuvant therapy; cancer radiotherapy; chemotherapy, adjuvant; cancer staging; lymph node metastasis; antineoplastic agent; cancer diagnosis; lymphatic metastasis; neoplasm staging; lymph node excision; clinical practice; lymphadenectomy; adenocarcinoma; metastasis; antineoplastic combined chemotherapy protocols; lung neoplasms; colonic neoplasms; nccn clinical practice guidelines; patient monitoring; practice guideline; pathology; oncology; cetuximab; tumor antigen; risk assessment; irinotecan; cancer invasion; standard; lung tumor; folinic acid; colon cancer; adjuvant chemotherapy; colon tumor; liver tumor; medical society; medical oncology; colon resection; medical specialist; physician; colorectal surgery; neoplasm invasiveness; neoplasm recurrence; oxaliplatin; floxuridine; 5-fluorouracil; colon polyp; colonic polyps; primary health care; colostomy; colectomy |
| Journal Title: | Journal of the National Comprehensive Cancer Network |
| Volume: | 3 |
| Issue: | 4 |
| ISSN: | 1540-1405 |
| Publisher: | Harborside Press |
| Date Published: | 2005-07-01 |
| Start Page: | 468 |
| End Page: | 491 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 16038639 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 30" - "Export Date: 24 October 2012" - "Source: Scopus" |
