Randomized clinical trials in colon cancer Journal Article
| Authors: | Neuman, H. B.; Park, J.; Weiser, M. R. |
| Article Title: | Randomized clinical trials in colon cancer |
| Abstract: | Surgery remains the mainstay of treatment for colon cancer and surgical resection alone results in 5-year survival in more than 60% of patients. However, the use of fluorouracil (5-FU)-based adjuvant chemotherapy for patients at high risk of recurrence further prolongs disease-free survival and has become the standard of care. New areas of research focus on decreasing the surgical trauma with minimally invasive approaches, improving the surgical staging of patients with colon cancer, and improving adjuvant treatment regimens. We review those randomized controlled trials that have most impacted the clinical management of patients with colon cancer in 2009. © 2010 Elsevier Inc. All rights reserved. |
| Keywords: | cancer survival; treatment outcome; surgical technique; clinical trial; review; cancer recurrence; fluorouracil; placebo; cancer combination chemotherapy; diarrhea; drug efficacy; drug potentiation; unspecified side effect; capecitabine; cancer adjuvant therapy; cancer staging; drug megadose; neurotoxicity; lymph node metastasis; laparoscopic surgery; sentinel lymph node biopsy; low drug dose; controlled clinical trial; multiple cycle treatment; sensory neuropathy; bleeding; gastrointestinal symptom; randomized controlled trial; colonic neoplasms; randomized controlled trials as topic; vincristine; lomustine; irinotecan; colorectal carcinoma; febrile neutropenia; drug fatality; folinic acid; colon cancer; surgery; colon resection; intermethod comparison; colon carcinoma; oxaliplatin; hemicolectomy; repeated drug dose; anastomosis leakage; colon anastomosis; adjuvant; levamisole; uft |
| Journal Title: | Surgical Oncology Clinics of North America |
| Volume: | 19 |
| Issue: | 1 |
| ISSN: | 1055-3207 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-01-01 |
| Start Page: | 183 |
| End Page: | 204 |
| Language: | English |
| DOI: | 10.1016/j.soc.2009.09.010 |
| PUBMED: | 19914566 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "CODEN: SOCAF" - "Source: Scopus" |
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