New agents for the treatment of ovarian cancer: The next generation Journal Article

  


Authors: Dupont, J.; Aghajanian, C.; Sabbatini, P.; Spriggs, D. R.
Article Title: New agents for the treatment of ovarian cancer: The next generation
Abstract: Ovarian cancer shares many important characteristics with more common malignancies including breast, lung, and colon cancer. The relative chemosensitivity of ovarian cancer and other aspects of its unique biology provide opportunities for novel interventions. In this brief summary, some of the potential targets in ovarian cancer are discussed, including the HER kinases, heat shock protein, the 26S proteasome, and the angiogenesis pathway. The opportunities to change the treatment of ovarian cancer will require creative clinical trial design but the next decade promises to be filled the therapeutic advances for patients with ovarian cancer. © 2005 IGCS.
Keywords: protein kinase b; treatment response; vascular endothelial growth factor a; unclassified drug; drug activity; review; cisplatin; erlotinib; antineoplastic agents; drug targeting; paclitaxel; treatment; ovarian cancer; ovarian neoplasms; drug inhibition; vasculotropin receptor; bortezomib; proteasome; ovary cancer; boronic acids; protease inhibitors; proteasome endopeptidase complex; pyrazines; protein degradation; protein targeting; epidermal growth factor receptor; epidermal growth factor receptor 2; chemosensitivity; angiogenesis; cetuximab; protein p53; telomerase; cancer therapy; protein kinase inhibitors; antibodies, monoclonal; drug mechanism; gefitinib; heat shock protein 90; hsp90 heat-shock proteins; ca 125 antigen; ca-125 antigen; trastuzumab; angiogenesis inhibitors; drug binding; infusions, parenteral; lactams, macrocyclic; ixabepilone; tubulin modulators; paclitaxel poliglumex; neoplasms, glandular and epithelial; geldanamycin; heat shock protein; ansamycin derivative; herbimycin a; 17 allylamino 17 demethoxygeldanamycin; new drugs; kos 102
Journal Title: International Journal of Gynecological Cancer
Volume: 15
Issue: 6 SUPPL. 3
ISSN: 1048-891X
Publisher: Lippincott Williams & Wilkins  
Date Published: 2005-11-01
Start Page: 252
End Page: 257
Language: English
DOI: 10.1111/j.1525-1438.2005.00443.x
PUBMED: 16343241
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-30744474499&partnerID=40&md5=3424a9e7de31f71cfc2406caab6ab7bf
Notes: --- - "Cited By (since 1996): 11" - "Export Date: 24 October 2012" - "CODEN: IJGCE" - "Source: Scopus"
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MSK Authors
  1. Jakob Dupont
    65 Dupont
  2. Paul J Sabbatini
    262 Sabbatini
  3. Carol A Aghajanian
    607 Aghajanian
  4. David R Spriggs
    325 Spriggs
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