Right place, right time, right peptide: DO keeps DM focused Journal Article
| Authors: | Denzin, L. K.; Fallas, J. L.; Prendes, M.; Yi, W. |
| Article Title: | Right place, right time, right peptide: DO keeps DM focused |
| Abstract: | Peptide loading of major histocompatibility class II molecules is catalyzed in late endosomal and lysosomal compartments of cells by the catalytic action of human leukocyte antigen (HLA)-DM (H-2M in mice). In B cells, dendritic cells and thymic epithelial cells, the peptide loading of class II molecules is modified by the expression of the non-classical class II molecule, HLA-DO (H-2O in mice). Collectively, studies to date support that DO/H-2O expression inhibits the presentation of antigens acquired by cells via fluid phase endocytosis. However, in B cells, the expression of H-2O promotes the presentation of antigens internalized by the B-cell receptor. In this review, we summarize the literature pertaining to DO assembly, transport, and function, with an emphasis on the function of DO/H-2O. Copyright © Blackwell Munksgaard 2005. |
| Keywords: | protein expression; review; nonhuman; protein function; protein localization; animals; protein assembly; in vivo study; cell differentiation; in vitro study; b-lymphocytes; antigen presentation; lymphocyte activation; immune response; protein transport; peptides; cellular distribution; down regulation; hla dm antigen; hla do antigen; hla-d antigens; b lymphocyte differentiation |
| Journal Title: | Immunological Reviews |
| Volume: | 207 |
| ISSN: | 0105-2896 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2005-10-01 |
| Start Page: | 279 |
| End Page: | 292 |
| Language: | English |
| DOI: | 10.1111/j.0105-2896.2005.00302.x |
| PUBMED: | 16181343 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 20" - "Export Date: 24 October 2012" - "CODEN: IMRED" - "Source: Scopus" |
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