Intensity-modulated radiation therapy for head and neck cancer Journal Article
| Authors: | Chou, W. W.; Puri, D. R.; Lee, N. Y. |
| Article Title: | Intensity-modulated radiation therapy for head and neck cancer |
| Abstract: | Radiotherapy planning studies have confirmed dosimetric advantages of intensity-modulated radiation therapy over conventional and conformal radiation therapy. Utilization of intensity-modulated radiation therapy is ideal in head and neck cancer patients. Critical structures can be spared due to sharp dose gradients and limited organ motion with correct immobilization. Initial clinical results have shown excellent locoregional control, in part due to the delivery of high doses to the target volume. Reductions in acute toxicities and xerostomia through parotid sparing have been notable benefits. However, long-term outcomes with regards to local control and late toxicities with intensity-modulated radiation therapy are still lacking. This review focuses on the implementation of intensity-modulated radiation therapy for the treatment of head and neck cancers, with a specific focus on set-up uncertainties, dose prescription and target volume determination and delineation. © 2005 Future Drugs Ltd. |
| Keywords: | treatment outcome; review; intensity modulated radiation therapy; cancer patient; radiation dose; nuclear magnetic resonance imaging; accuracy; quality of life; computer assisted tomography; tumor volume; radiotherapy; risk factors; radiation injury; dose-response relationship, radiation; head and neck cancer; head and neck neoplasms; dosimetry; long term care; radiation injuries; xerostomia; radiotherapy, conformal; cancer control; dose fractionation; computer assisted radiotherapy; radiation dose distribution; parotid gland; intensity-modulated radiation therapy; immobilization; movement; volume delineation |
| Journal Title: | Expert Review of Anticancer Therapy |
| Volume: | 5 |
| Issue: | 3 |
| ISSN: | 1473-7140 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2005-06-01 |
| Start Page: | 515 |
| End Page: | 521 |
| Language: | English |
| DOI: | 10.1586/14737140.5.3.515 |
| PUBMED: | 16001958 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 5" - "Export Date: 24 October 2012" - "CODEN: ERATB" - "Source: Scopus" |
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