Proposal of a new grading system for malignant fibrous histiocytomas Journal Article

Authors: Brinck, U.; Cordon-Cardo, C.; Stachura, J.; Bortkiewicz, P.; Fischer, G.; Korabiowska, M.
Article Title: Proposal of a new grading system for malignant fibrous histiocytomas
Abstract: The proposed grading system for malignant fibrous histiocytomas (MFH) comprises 3 grades of malignancy. Analogous to other grading systems, the system includes the factors of mitotic rate and necrosis. In addition to these two factors, the concept of cellularity was included. The prognostic relevance of the grading systems published by Costa, Coindre, van Unnik, Pezzi and Tsujimoto as well as the grading system proposed by the present study was tested on 161 MFH. The results showed that all grading systems tested produced clearly significant differences (p < 0.01) with regard to the survival estimated for patients with various grades of malignancy. These results revealed the superiority of systems that use 3 grades of malignancy over a 2-grade classification. The proposed grading system yielded a lower percentage of grade II tumours (37%) than the grading systems of Coindre (60%) and van Unnik (70%). In the multivariate analysis of all grading systems, the proposed grading system was the only one to show prognostic relevance (p < 0.05).
Keywords: adolescent; adult; cancer survival; child; controlled study; human tissue; aged; aged, 80 and over; child, preschool; middle aged; human cell; major clinical study; histopathology; cancer grading; statistical significance; predictive value of tests; mitosis rate; multivariate analysis; cancer classification; malignant fibrous histiocytoma; histiocytoma, malignant fibrous; tissue necrosis; grading; mfh
Journal Title: Anticancer Research
Volume: 25
Issue: 6 B
ISSN: 0250-7005
Publisher: International Institute of Anticancer Research  
Date Published: 2005-11-01
Start Page: 4293
End Page: 4298
Language: English
PUBMED: 16309231
PROVIDER: scopus
Notes: --- - "Cited By (since 1996): 1" - "Export Date: 24 October 2012" - "CODEN: ANTRD" - "Source: Scopus"
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