Analysis of the p53-hMDM2-p21 (WAF1/CIP1) cell cycle regulation pathway in malignant fibrous histiocytomas Journal Article

  


Authors: Brinck, U.; Schlott, T.; Cordon-Cardo, C.; Stachura, J.; Walz, M.; Fischer, G.; Korabiowska, M.
Article Title: Analysis of the p53-hMDM2-p21 (WAF1/CIP1) cell cycle regulation pathway in malignant fibrous histiocytomas
Abstract: This study was undertaken to analyze patterns of expression of critical cell cycle regulators (CCR) involved in the p53 pathway in malignant fibrous histiocytomas (MFH). Protein expression was assessed using immunohistochemistry analyzing p53, hMDM2 and p21 (WAF1/CIP1) phenotypes. p53- and hMDM2-positive phenotypes were found to be associated with low p21 levels (p0.01). Positive hMDM2 phenotype did not correlate with any hMDM2 mutations, which in our tumor collective were not found. High-grade MFH differed from MFH grade I and II concerning higher p53 and lower p21 levels, while hMDM2 expression was independent of grade. Inclusion of categorized values into a Cox regression study proved the independent prognostic relevance of p53, hMDM2 and p21 phenotypes.
Keywords: cell cycle regulators; p53; p21; mdm2; mfh
Journal Title: Cancer Genomics and Proteomics
Volume: 1
Issue: 5-6
ISSN: 1109-6535
Publisher: The International Institute of Anticancer Research  
Date Published: 2004-09-01
Start Page: 419
End Page: 426
Language: English
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-33750742894&partnerID=40&md5=2d4de281095c15308fc7133bb87294bd
Notes: Cancer Genomics Proteomics -- Cited By (since 1996):1 -- Export Date: 16 June 2014 -- Source: Scopus