Left-right patterning in the C. elegans embryo: Unique mechanisms and common principles Journal Article

Author: Pohl, C.
Article Title: Left-right patterning in the C. elegans embryo: Unique mechanisms and common principles
Abstract: The development of bilateral symmetry during the evolution of species probably 600 million years ago brought about several important innovations: It fostered efficient locomotion, streamlining and favored the development of a central nervous system through cephalization. However, to increase their functional capacities, many organisms exhibit chirality by breaking their superficial left-right (l-r) symmetry, which manifests in the lateralization of the nervous system or the l-r asymmetry of internal organs. In most bilateria, the mechanisms that maintain consistent l-r asymmetry throughout development are poorly understood. This review highlights insights into mechanisms that couple early embryonic l-r symmetry breaking to subsequent l-r patterning in the roundworm Caenorhabditis elegans. A recently identified strategy for l-r patterning in the early C. elegans embryo is discussed, the spatial separation of midline and anteroposterior axis, which relies on a rotational cellular rearrangement and non-canonical wnt signaling. evidence for a general relevance of rotational/torsional rearrangements during organismal l-r patterning and for non-canonical wnt signaling/planar cell polarity as a common signaling mechanism to maintain l-r asymmetry is presented. © 2011 Landes Bioscience.
Keywords: embryonic development; planar cell polarity; left-right axis; symmetry breaking; wnt signaling
Journal Title: Communitative and Integrative Biology
Volume: 4
Issue: 1
ISSN: 1942-0889
Publisher: Landes Bioscience  
Date Published: 2011-01-01
Start Page: 34
End Page: 40
Language: English
PROVIDER: scopus
PMCID: PMC3073266
PUBMED: 21509174
DOI: 10.4161/cib.4.1.14144
Notes: --- - "Export Date: 4 March 2011" - "Source: Scopus"
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MSK Authors
  1. Christian Pohl
    5 Pohl