High incidence of thrombosis in African-American and Latin-American patients with Paroxysmal Nocturnal Haemoglobinuria Journal Article
| Authors: | Araten, D. J.; Thaler, H. T.; Luzzatto, L. |
| Article Title: | High incidence of thrombosis in African-American and Latin-American patients with Paroxysmal Nocturnal Haemoglobinuria |
| Abstract: | Paroxysmal Nocturnal Haemoglobinuria (PNH) results in a marked thrombophilic state by unknown mechanisms. Geographic differences in thrombosis incidence in PNH have been observed. We have reviewed 64 patients with "Classic PNH" from a single institution in order to determine the rate of thrombosis in different ethnic groups. When we compared African-Americans (n=11) and Latin-Americans (n=8) with other patients (n=45), we found that African-American and Latin-American patients are at increased risk [Hazard ratio 3.66 (p=0.005) and 3.52, (p= 0.035) respectively by Cox regression]. Our data also suggest that this difference in the rate of thrombosis has an impact on length of survival. These findings demonstrate that ethnicity is a risk factor for thrombosis in PNH and have implications for decision-making regarding the management of these patients, including the prevention of thrombosis. © 2005 Schattauer GmbH, Stuttgart. |
| Keywords: | adolescent; adult; child; controlled study; aged; middle aged; survival analysis; survival rate; major clinical study; united states; medical decision making; incidence; risk factors; risk factor; risk assessment; survival time; thrombosis; ethnic difference; regression analysis; african americans; ethnicity; african american; tissue plasminogen activator; paroxysmal nocturnal hemoglobinuria; hemoglobinuria, paroxysmal; hispanic; anticoagulant agent; latin america; ethnic groups; thrombophilia; geographic distribution; deep venous thrombosis; hypercoagulable states; paroxysmal nocturnal hemoglobinuria (pnh) |
| Journal Title: | Thrombosis and Haemostasis |
| Volume: | 93 |
| Issue: | 1 |
| ISSN: | 0340-6245 |
| Publisher: | Schattauer Publishers, Stuttgart |
| Date Published: | 2005-01-01 |
| Start Page: | 88 |
| End Page: | 91 |
| Language: | English |
| DOI: | 10.1160/th04-06-0391 |
| PUBMED: | 15630496 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 18" - "Export Date: 24 October 2012" - "CODEN: THHAD" - "Source: Scopus" |
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