High incidence of thrombosis in African-American and Latin-American patients with Paroxysmal Nocturnal Haemoglobinuria Journal Article


Authors: Araten, D. J.; Thaler, H. T.; Luzzatto, L.
Article Title: High incidence of thrombosis in African-American and Latin-American patients with Paroxysmal Nocturnal Haemoglobinuria
Abstract: Paroxysmal Nocturnal Haemoglobinuria (PNH) results in a marked thrombophilic state by unknown mechanisms. Geographic differences in thrombosis incidence in PNH have been observed. We have reviewed 64 patients with "Classic PNH" from a single institution in order to determine the rate of thrombosis in different ethnic groups. When we compared African-Americans (n=11) and Latin-Americans (n=8) with other patients (n=45), we found that African-American and Latin-American patients are at increased risk [Hazard ratio 3.66 (p=0.005) and 3.52, (p= 0.035) respectively by Cox regression]. Our data also suggest that this difference in the rate of thrombosis has an impact on length of survival. These findings demonstrate that ethnicity is a risk factor for thrombosis in PNH and have implications for decision-making regarding the management of these patients, including the prevention of thrombosis. © 2005 Schattauer GmbH, Stuttgart.
Keywords: adolescent; adult; child; controlled study; aged; middle aged; survival analysis; survival rate; major clinical study; united states; medical decision making; incidence; risk factors; risk factor; risk assessment; survival time; thrombosis; ethnic difference; regression analysis; african americans; ethnicity; african american; tissue plasminogen activator; paroxysmal nocturnal hemoglobinuria; hemoglobinuria, paroxysmal; hispanic; anticoagulant agent; latin america; ethnic groups; thrombophilia; geographic distribution; deep venous thrombosis; hypercoagulable states; paroxysmal nocturnal hemoglobinuria (pnh)
Journal Title: Thrombosis and Haemostasis
Volume: 93
Issue: 1
ISSN: 0340-6245
Publisher: Schattauer Publishers, Stuttgart  
Date Published: 2005-01-01
Start Page: 88
End Page: 91
Language: English
DOI: 10.1160/th04-06-0391
PUBMED: 15630496
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 18" - "Export Date: 24 October 2012" - "CODEN: THHAD" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Howard T Thaler
    193 Thaler
  2. David Araten
    20 Araten
  3. Lucio Luzzatto
    104 Luzzatto