Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma Journal Article

  

Authors:	Abrey, L. E.; Batchelor, T. T.; Ferreri, A. J. M.; Gospodarowicz, M.; Pulczynski, E. J.; Zucca, E.; Smith, J. R.; Korfel, A.; Soussain, C.; De Angelis, L. M.; Neuwelt, E. A.; O'Neill, B. P.; Thiel, E.; Shenkier, T.; Graus, F.; Van Den Bent, M.; Seymour, J. F.; Poortmans, P.; Armitage, J. O.; Cavalli, F.
Article Title:	Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma
Abstract:	Standardized guidelines for the baseline evaluation and response assessment of primary CNS lymphoma (PCNSL) are critical to ensure comparability among clinical trials for newly diagnosed patients. The relative rarity of this tumor precludes rapid completion of large-scale phase III trials and, therefore, our reliance on the results of well-designed phase II trials is critical. To formulate this recommendation, an international group of experts representing hematologic oncology, medical oncology, neuro-oncology, neurology, radiation oncology, neurosurgery, and ophthalmology met to review current standards of reporting and to formulate a consensus opinion regarding minimum baseline evaluation and common standards for assessing response to therapy. The response guidelines were based on the results of neuroimaging, corticosteroid use, ophthalmologic examination, and CSF cytology. A critical issue that requires additional study is the optimal method to assess the neurocognitive impact of therapy and address the quality of life of PCNSL survivors. We hope that these guidelines will improve communication among investigators and comparability among clinical trials in a way that will allow us to develop better therapies for patients. © 2005 by American Society of Clinical Oncology.
Keywords:	cancer survival; treatment response; clinical trial; review; gadolinium; neuroimaging; follow up; quality of life; practice guideline; publication; central nervous system tumor; standardization; laboratory test; lymphoma; clinical evaluation; scoring system; corticosteroid derivative; cognition; reliability; drug use; eye examination; cerebrospinal fluid cytology
Journal Title:	Journal of Clinical Oncology
Volume:	23
Issue:	22
ISSN:	0732-183X
Publisher:	American Society of Clinical Oncology
Date Published:	2005-08-01
Start Page:	5034
End Page:	5043
Language:	English
DOI:	10.1200/jco.2005.13.524
PROVIDER:	scopus
PUBMED:	15955902
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-24644432553&partnerID=40&md5=368dde6cb10942b1d8dd4861ea557603
Notes:	--- - "Cited By (since 1996): 125" - "Export Date: 24 October 2012" - "CODEN: JCOND" - "Source: Scopus"

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