Liquid biopsy for improving diagnosis and monitoring of CNS lymphomas: A RANO review Review
| Authors: | Nayak, L.; Bettegowda, C.; Scherer, F.; Galldiks, N.; Ahluwalia, M.; Baraniskin, A.; von Baumgarten, L.; Bromberg, J. E. C.; Ferreri, A. J. M.; Grommes, C.; Hoang-Xuan, K.; Kühn, J.; Rubenstein, J. L.; Rudà, R.; Weller, M.; Chang, S. M.; van den Bent, M. J.; Wen, P. Y.; Soffietti, R. |
| Review Title: | Liquid biopsy for improving diagnosis and monitoring of CNS lymphomas: A RANO review |
| Abstract: | Background. The utility of liquid biopsies is well documented in several extracranial and intracranial (brain/leptomeningeal metastases, gliomas) tumors. Methods. The RANO (Response Assessment in Neuro-Oncology) group has set up a multidisciplinaryTask Force to critically review the role of blood and cerebrospinal fluid (CSF)–liquid biopsy in CNS lymphomas, with a main focus on primary central nervous system lymphomas (PCNSL). Results. Several clinical applications are suggested: diagnosis of PCNSL in critical settings (elderly or frail patients, deep locations, and steroid responsiveness), definition of minimal residual disease, early indication of tumor response or relapse following treatments, and prediction of outcome. Conclusions. Thus far, no clinically validated circulating biomarkers for managing both primary and secondary CNS lymphomas exist.There is need of standardization of biofluid collection, choice of analytes, and type of technique to perform the molecular analysis.The various assays should be evaluated through well-organized central testing within clinical trials. © The Author(s) 2024. |
| Keywords: | gene mutation; overall survival; histopathology; review; primary central nervous system lymphoma; flow cytometry; nuclear magnetic resonance imaging; prospective study; sensitivity and specificity; genetic analysis; monitoring; tumor volume; prevalence; tumor biopsy; cell differentiation; pathology; mutational analysis; tumor marker; cancer research; cancer therapy; dna methylation; central nervous system tumor; central nervous system; central nervous system neoplasms; carcinogenesis; blood; gene rearrangement; immune response; cerebrospinal fluid; bone marrow biopsy; systematic review; diagnosis; blood brain barrier; lymphoma; nuclear magnetic resonance spectroscopy; immunophenotyping; real time polymerase chain reaction; upregulation; enzyme linked immunospot assay; dna extraction; epstein barr virus; predictive value; cerebrospinal fluid cytology; whole brain radiotherapy; corpus callosum; gray matter; tumor invasion; procedures; machine learning; high throughput sequencing; humans; prognosis; human; circulating tumor dna; droplet digital polymerase chain reaction; csf biomarkers; liquid biopsy; biomarkers, tumor; myd88 mutations; primary cns lymphomas; secondary cns lymphomas |
| Journal Title: | Neuro-Oncology |
| Volume: | 26 |
| Issue: | 6 |
| ISSN: | 1522-8517 |
| Publisher: | Oxford University Press |
| Date Published: | 2024-06-01 |
| Start Page: | 993 |
| End Page: | 1011 |
| Language: | English |
| DOI: | 10.1093/neuonc/noae032 |
| PUBMED: | 38598668 |
| PROVIDER: | scopus |
| PMCID: | PMC11145457 |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
