Controversies in primary CNS lymphoma Journal Article
| Author: | Abrey, L. E. |
| Article Title: | Controversies in primary CNS lymphoma |
| Abstract: | Primary CNS lymphoma is a non-Hodgkin's lymphoma confined to the CNS: the brain, eyes and cerebrospinal fluid. Unlike other primary brain tumors, primary CNS lymphoma is uniquely chemo- and radiosensitive. However, the outcome of primary CNS lymphoma patients is significantly inferior to similar non-Hodgkin's lymphoma patients. Multiple prospective studies using high-dose methotrexate, with or without whole-brain radiotherapy, have reported improved primary CNS lymphoma outcome, but numerous questions remain regarding the optimal care of a given patient. © 2005 Future Drugs Ltd. |
| Keywords: | treatment outcome; clinical trial; review; cancer recurrence; doxorubicin; drug penetration; antineoplastic agents; cancer radiotherapy; radiation dose; chemotherapy; cytarabine; ibritumomab tiuxetan; methotrexate; rituximab; temozolomide; drug megadose; molecular genetics; neurotoxicity; brain tumor; antineoplastic agent; carboplatin; cancer immunotherapy; etoposide; radiotherapy; cyclophosphamide; dexamethasone; melphalan; vincristine; stem cell transplantation; chemosensitivity; carmustine; ifosfamide; lomustine; procarbazine; thiotepa; central nervous system tumor; central nervous system neoplasms; monoclonal antibody; patient care; prednisolone; nonhodgkin lymphoma; immunotherapy; cerebrospinal fluid; lymphoma, non-hodgkin; urine incontinence; dementia; radiosensitivity; methylprednisolone; primary cns lymphoma; corticosteroid; drug dose regimen; teniposide; gait disorder; eye tumor; cerebrospinal fluid level; cholesterol oxidase; thiosulfate |
| Journal Title: | Expert Review of Neurotherapeutics |
| Volume: | 5 |
| Issue: | 4 |
| ISSN: | 1473-7175 |
| Publisher: | Informa Healthcare |
| Date Published: | 2005-07-01 |
| Start Page: | 459 |
| End Page: | 464 |
| Language: | English |
| DOI: | 10.1586/14737175.5.4.459 |
| PUBMED: | 16026229 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 24 October 2012" - "CODEN: ERNXA" - "Source: Scopus" |
