Mix and match: Heterodimers and opioid tolerance Journal Article
| Authors: | Pasternak, G. W.; Pan, Y. X. |
| Article Title: | Mix and match: Heterodimers and opioid tolerance |
| Abstract: | Heterodimerization of G protein-coupled receptors has become increasingly recognized as a valuable mechanism to increase receptor diversity. Heterodimers have been observed in the opioid receptor family, but one of the most intriguing is that formed between μ-opioid and δ-opioid receptors. In this issue of Neuron, He et al. present evidence further implicating these heterodimers in morphine tolerance. © 2011 Elsevier Inc. |
| Keywords: | protein expression; nonhuman; protein domain; opiate; genetic variability; messenger rna; protein transport; alternative rna splicing; cyclic amp; short survey; dimerization; molecular interaction; morphine; protein family; heterodimer; analgesia; g protein coupled receptor; mu opiate receptor; nitric oxide synthase; morphine tolerance; opiate receptor; naltrindole; alpha 2 adrenergic receptor; delta opiate receptor; deltorphin; glycoprotein p; n methyl dextro aspartic acid receptor; neurokinin 1 receptor; nitric oxide; spinal ganglion |
| Journal Title: | Neuron |
| Volume: | 69 |
| Issue: | 1 |
| ISSN: | 0896-6273 |
| Publisher: | Cell Press |
| Date Published: | 2011-01-13 |
| Start Page: | 6 |
| End Page: | 8 |
| Language: | English |
| DOI: | 10.1016/j.neuron.2010.12.030 |
| PROVIDER: | scopus |
| PMCID: | PMC3027205 |
| PUBMED: | 21318174 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 4 March 2011" - "CODEN: NERNE" - "Source: Scopus" |
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