| Abstract: |
Chronic systemic treatment with the opioid antagonist, naltrexone, increased the analgesic potency of intrathecally administered opioid agonists at spinal μ and δ receptors, but not at κ{script} receptors. These results indicate that, contrary to a previous report, opioid receptors in the spinal cord display up-regulation and supersensitivity and are no different in this regard from supraspinal receptors. © 1989. |
| Keywords: |
nonhuman; mouse; animal; metabolism; mice; animal experiment; drug effect; physiology; spinal cord; up-regulation; analgesia; mu opiate receptor; receptors, opioid, mu; opiate receptor; enkephalin[2,5 dextro penicillamine]; naltrexone; opioid receptor; delta opiate receptor; receptor subtype; receptors, opioid, delta; ethylketazocine; enkephalin[2 dextro alanine 4 methylphenylalanine 5 glycine]; subcutaneous drug administration; receptors, opioid; male; priority journal; article; opioid peptide; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; spinal analgesia; intrathecal drug administration; supersensitivity; opiod
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