The tricky path to recombining X and Y chromosomes in meiosis Conference Paper


Authors: Kauppi, L.; Jasin, M.; Keeney, S.
Title: The tricky path to recombining X and Y chromosomes in meiosis
Conference Title: DIMACS Conference on Effects of Genome Structure and Sequence on the Generation of Variation and Evolution
Abstract: Sex chromosomes are the Achilles' heel of male meiosis in mammals. Mis-segregation of the X and Y chromosomes leads to sex chromosome aneuploidies, with clinical outcomes such as infertility and Klinefelter syndrome. Successful meiotic divisions require that all chromosomes find their homologous partner and achieve recombination and pairing. Sex chromosomes in males of many species have only a small region of homology (the pseudoautosomal region, PAR) that enables pairing. Until recently, little was known about the dynamics of recombination and pairing within mammalian X and Y PARs. Here, we review our recent findings on PAR behavior in mouse meiosis. We uncovered unexpected differences between autosomal chromosomes and the X-Y chromosome pair, namely that PAR recombination and pairing occurs later, and is under different genetic control. These findings imply that spermatocytes have evolved distinct strategies that ensure successful X-Y recombination and chromosome segregation. © 2012 New York Academy of Sciences..
Keywords: meiosis; chromosome pairing; recombination; sex chromosomes
Journal Title Annals of the New York Academy of Sciences
Volume: 1267
Issue: 1
Conference Dates: 2011 Aug 9-11
Conference Location: New Brunswick, NJ
ISBN: 0077-8923
Publisher: John Wiley & Sons  
Date Published: 2012-09-01
Start Page: 18
End Page: 23
Language: English
DOI: 10.1111/j.1749-6632.2012.06593.x
PROVIDER: scopus
PUBMED: 22954211
PMCID: PMC3631422
DOI/URL:
Notes: --- - "Cited By (since 1996): 2" - "Export Date: 1 October 2012" - "CODEN: ANYAA" - "Source: Scopus"
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MSK Authors
  1. Scott N Keeney
    113 Keeney
  2. Liisa Hannele Kauppi
    10 Kauppi
  3. Maria Jasin
    224 Jasin