The effect of age in the outcome and treatment of older women with ductal carcinoma in situ Journal Article


Authors: Ho, A.; Goenka, A.; Ishill, N.; Van Zee, K.; McLane, A.; Gonzales, A. M.; Tan, L.; Cody, H.; Powell, S.; McCormick, B.
Article Title: The effect of age in the outcome and treatment of older women with ductal carcinoma in situ
Abstract: The effect of increasing age on outcomes and type of treatment given to older women with ductal carcinoma in situ (DCIS) was assessed. 646 women ≥60 years old (654 cases) receiving surgery for DCIS at Memorial Sloan-Kettering Cancer Center between 2000 and 2007 (8 bilateral) had wide local excision (WLE; 37%), WLE plus radiotherapy (WLE. +. RT; 41%), or mastectomy (22%). 45%, 38%, and 16% of patients 60-69 years, 70-79 years, and ≥80 years, respectively, received WLE. +. RT (P< 0.001) and 25%, 20%, and 13%, received mastectomy, respectively (P< 0.001). Age (P< 0.001), grade (P< 0.001), and necrosis (P< 0.01) were highly associated with treatment. Four-year local recurrence was 3.6%. Overall local recurrence differed by treatment (mastectomy, 0%; WLE, 5%; WLE. +. RT, 4%; P< 0.00001) but not age. It is possible to identify older women with DCIS in whom the risk of recurrence is acceptably low after WLE alone. WLE alone may be a viable treatment option for select older women with DCIS. © 2010.
Keywords: radiotherapy; ductal carcinoma; in situ; older women; wide local excision
Journal Title: Breast
Volume: 20
Issue: 1
ISSN: 0960-9776
Publisher: Elsevier Inc.  
Date Published: 2011-02-01
Start Page: 71
End Page: 77
Language: English
DOI: 10.1016/j.breast.2010.07.005
PROVIDER: scopus
PUBMED: 20739181
DOI/URL:
Notes: --- - "Export Date: 4 March 2011" - "CODEN: BREAE" - "Source: Scopus"
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Citation Impact
MSK Authors
  1. Alice Yoosun Ho
    122 Ho
  2. Simon Nicholas Powell
    300 Powell
  3. Lee K Tan
    145 Tan
  4. Kimberly J Van Zee
    289 Van Zee
  5. Hiram S Cody III
    241 Cody
  6. Anuj Goenka
    18 Goenka
  7. Beryl McCormick
    359 McCormick
  8. Nicole Marie Leoce
    86 Leoce
  9. Amanda Foster
    63 Foster