From the bottle to the skin: Challenges in evaluating antioxidants Journal Article


Authors: Chen, L. L.; Wang, S. Q.
Article Title: From the bottle to the skin: Challenges in evaluating antioxidants
Abstract: Endogenous production and ultraviolet-generated free radicals in the skin can lead to photoaging and even skin cancer. Topical antioxidants have been found to provide benefits against ultraviolet damage and these ingredients have been incorporated into various cosmetic products and claimed to have substantial effects. Currently, there is a lack in a standardized rating system to measure the concentration and activity levels of antioxidants in these products. As a result, it is difficult for consumers and clinicians to evaluate and select commercial products based on readily accessible evidence. In this review, we will describe four assays which have been used to measure antioxidants in various products, and the strengths and weaknesses of each test will be detailed. We will highlight key considerations for clinicians when interpreting the results of antioxidant tests when evaluating commercial products containing antioxidants. © 2012 John Wiley & Sons A/S.
Keywords: review; nonhuman; ultraviolet radiation; animals; fluorescence; assay; food intake; skin; reactive oxygen metabolite; cholesterol; flavonoid; spectrofluorometry; antioxidant; antioxidants; alpha tocopherol; ascorbic acid; ultraviolet rays; lipophilicity; ultraviolet irradiation; fluorescein; hydrophilicity; carotenoid; free radicals; phytochemistry; electron transport; electron spin resonance; cosmetics; food analysis; antioxidant assays; oxygen radical absorbance capacity; trolox equivalent antioxidant capacity; lanolin; skin lipid; squalene; stearic acid; lipid oxidation; oxidative stability index; oxygen radical absorbance capacity assay; trolox equivalent antioxidant capacity assay
Journal Title: Photodermatology Photoimmunology and Photomedicine
Volume: 28
Issue: 5
ISSN: 0905-4383
Publisher: Blackwell Publishing  
Date Published: 2012-10-01
Start Page: 228
End Page: 234
Language: English
DOI: 10.1111/j.1600-0781.2012.00674.x
PROVIDER: scopus
PUBMED: 22971186
DOI/URL:
Notes: --- - "Export Date: 1 October 2012" - "CODEN: PPPHE" - "Source: Scopus"
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MSK Authors
  1. Steven Q Wang
    73 Wang
  2. Lucy Lugun Chen
    11 Chen