MIRD pamphlet no. 23: Quantitative SPECT for patient-specific 3-dimensional dosimetry in internal radionuclide therapy Journal Article
| Authors: | Dewaraja, Y. K.; Frey, E. C.; Sgouros, G.; Brill, A. B.; Roberson, P.; Zanzonico, P. B.; Ljungberg, M. |
| Article Title: | MIRD pamphlet no. 23: Quantitative SPECT for patient-specific 3-dimensional dosimetry in internal radionuclide therapy |
| Abstract: | In internal radionuclide therapy, a growing interest in voxel-level estimates of tissue-absorbed dose has been driven by the desire to report radiobiologic quantities that account for the biologic consequences of both spatial and temporal nonuniformities in these dose estimates. This report presents an overview of 3-dimensional SPECT methods and requirements for internal dosimetry at both regional and voxel levels. Combined SPECT/CT image-based methods are emphasized, because the CT-derived anatomic information allows one to address multiple technical factors that affect SPECT quantification while facilitating the patient-specific voxel-level dosimetry calculation itself. SPECT imaging and reconstruction techniques for quantification in radionuclide therapy are not necessarily the same as those designed to optimize diagnostic imaging quality. The current overview is intended as an introduction to an upcoming series of MIRD pamphlets with detailed radionuclide-specific recommendations intended to provide best-practice SPECT quantification-based guidance for radionuclide dosimetry. Copyright © 2012 by the Society of Nuclear Medicine and Molecular Imaging, Inc. |
| Keywords: | review; nonhuman; radiation dose; technetium 99m; diagnostic accuracy; computer assisted tomography; image analysis; radiotherapy dosage; calibration; diagnostic imaging; iodine 131; dosimetry; image quality; three dimensional imaging; imaging, three-dimensional; collimator; radiometry; radioisotope; image processing, computer-assisted; etidronic acid tc 99m; single photon emission computer tomography; radioisotopes; artifacts; image display; radioisotope therapy; image reconstruction; radiation scattering; tomography, emission-computed, single-photon; scattering, radiation; documentation; individualized medicine; process optimization; radiation detector; radiation detection; camera; radiation attenuation; quantitative diagnosis; filtration; radionuclide therapy; radiation depth dose; absorbed dose; 3d dosimetry; mird; patient-specific dosimetry; quantitative spect; image retrieval |
| Journal Title: | Journal of Nuclear Medicine |
| Volume: | 53 |
| Issue: | 8 |
| ISSN: | 0161-5505 |
| Publisher: | Society of Nuclear Medicine |
| Date Published: | 2012-08-01 |
| Start Page: | 1310 |
| End Page: | 1325 |
| Language: | English |
| DOI: | 10.2967/jnumed.111.100123 |
| PROVIDER: | scopus |
| PUBMED: | 22743252 |
| PMCID: | PMC3465844 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 4 September 2012" - "CODEN: JNMEA" - "Source: Scopus" |
