Implementation of a Monte Carlo dosimetry method for patient-specific internal emitter therapy Journal Article
| Authors: | Furhang, E. E.; Chui, C. S.; Kolbert, K. S.; Larson, S. M.; Sgouros, G. |
| Article Title: | Implementation of a Monte Carlo dosimetry method for patient-specific internal emitter therapy |
| Abstract: | In internal emitter therapy, an accurate description of the absorbed dose distribution is necessary to establish an administered dose-response relationship, as well as to avoid critical organ toxicity. This work describes the implementation of a dosimetry method that accounts for the radionuclide decay spectrum, and patient-specific activity and density distributions. The dosimetry algorithm is based on a Monte Carlo procedure that simulates photon and electron transport and scores energy depositions within the patient. The necessary input information may be obtained from a registered set of CT and SPECT or PET images. The algorithm provides the absorbed dose rate for the radioactivity distribution provided by the SPECT or PET image. The algorithm was benchmarked by reproducing dosimetric quantities using the Medical Internal Radionuclide Dose (MIRD) Committee's Standard Man phantom and was used to calculate absorbed dose distributions for representative case studies. |
| Keywords: | leukemia; cancer radiotherapy; radiation dose; positron emission tomography; colorectal cancer; pancreas; metastasis; computer assisted tomography; bone marrow; spleen; radiotherapy dosage; liver; kidney; iodine 125; iodine 131; dosimetry; three dimensional imaging; iodine 124; thyroid cancer; radiotherapy planning, computer-assisted; radioisotope; radioimmunotherapy; single photon emission computer tomography; intravenous drug administration; monte carlo; monte carlo method; system analysis; iodine 123; patient-specific dosimetry; humans; human; priority journal; article |
| Journal Title: | Medical Physics |
| Volume: | 24 |
| Issue: | 7 |
| ISSN: | 0094-2405 |
| Publisher: | American Association of Physicists in Medicine |
| Date Published: | 1997-07-01 |
| Start Page: | 1163 |
| End Page: | 1172 |
| Language: | English |
| DOI: | 10.1118/1.598018 |
| PUBMED: | 9243479 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 17 March 2017 -- Source: Scopus |
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