Reducing the toxicity of cancer therapy: Recognizing needs, taking action Journal Article
| Authors: | Cleeland, C. S.; Allen, J. D.; Roberts, S. A.; Brell, J. M.; Giralt, S. A.; Khakoo, A. Y.; Kirch, R. A.; Kwitkowski, V. E.; Liao, Z.; Skillings, J. |
| Article Title: | Reducing the toxicity of cancer therapy: Recognizing needs, taking action |
| Abstract: | Our understanding of the biology of cancer and the application of this knowledge to cancer treatment has greatly outpaced what we know of the biology underlying the symptoms and toxic effects that therapies produce. These adverse effects of therapy cause substantial discomfort and distress to patients and their families, limit treatment tolerability and can persist indefinitely in post-treatment survivorship. Despite these concerns, little research effort is targeted at documenting the nature of these effects. Similarly, limited efforts are being made in the drug-development arena to identify or develop treatments that might prevent or reduce toxicities. A panel of clinicians and researchers as well as representatives from advocacy groups, federal agencies and the pharmaceutical industry was convened to identify gaps in cancer treatment toxicity research and to provide direction for future action. With an emphasis on coordinating multidisciplinary efforts, this panel has presented a strategy to increase funding for the field and develop a coherent research agenda. © 2012 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | cancer chemotherapy; cancer survival; leukemia; cancer surgery; fatigue; neutropenia; review; angiogenesis inhibitor; cytotoxic agent; hypertension; nonhuman; skin toxicity; antineoplastic agents; cancer radiotherapy; neurotoxicity; neoplasms; cancer palliative therapy; peripheral neuropathy; aromatase inhibitor; cancer pain; practice guideline; food and drug administration; radiation injury; protein tyrosine kinase inhibitor; cancer hormone therapy; hyperglycemia; pneumonia; postoperative complication; postoperative complications; health care policy; health care quality; cancer genetics; gastrointestinal toxicity; patient care; depression; symptom; medical education; ischemia; cardiotoxicity; thrombosis; medical research; patient safety; radiation injuries; distress syndrome; malignant neoplastic disease; cognitive defect; osteoporosis; antiandrogen; hypercholesterolemia; platinum complex; taxane derivative; immune deficiency; mammalian target of rapamycin inhibitor; anthracycline; antineoplastic antimetabolite; postmarketing surveillance; adverse drug reaction; patient care planning; hypertriglyceridemia; epidermal growth factor receptor kinase inhibitor; angioneurotic edema; gastroenteritis; antileukemic agent; patient advocacy; heart ventricle failure |
| Journal Title: | Nature Reviews Clinical Oncology |
| Volume: | 9 |
| Issue: | 8 |
| ISSN: | 1759-4774 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2012-07-03 |
| Start Page: | 471 |
| End Page: | 478 |
| Language: | English |
| DOI: | 10.1038/nrclinonc.2012.99 |
| PROVIDER: | scopus |
| PUBMED: | 22751283 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 4 September 2012" - "Source: Scopus" |
