The pediatric approach to Hodgkin lymphoma Review
| Authors: | Heneghan, M. B.; Belsky, J. A.; Milgrom, S. A.; Forlenza, C. J. |
| Review Title: | The pediatric approach to Hodgkin lymphoma |
| Abstract: | Hodgkin lymphoma (HL) occurs throughout the lifespan but is one of the most common cancers in adolescents and young adults (AYA; 15-39 years). HL has become a highly curable disease with survival rates surpassing 90%, including patients with high-risk and advanced stage disease. Unfortunately, intensive treatment carries a risk of short- and long-term toxicity. Given the decades pediatric HL survivors are expected to live after treatment, the pediatric approach to treatment has focused on improving the therapeutic index through response adapted treatment and more recently the incorporation of novel agents. The efforts of pediatric and medical oncologists in research and clinical trial development have long occurred in parallel, but recent efforts have laid the foundation for collaboration with the goal of standardizing AYA care and allowing earlier incorporation of novel therapy for younger patients. This review focuses on the evolution of the management of pediatric HL including epidemiology, biology, and approaches to upfront and salvage treatment regimens. © 2024 Elsevier Inc. |
| Keywords: | adolescent; child; event free survival; treatment response; young adult; overall survival; prednisone; histopathology; cancer recurrence; salvage therapy; doxorubicin; cancer risk; outcome assessment; antineoplastic agent; cancer incidence; progression free survival; antineoplastic combined chemotherapy protocols; morbidity; cyclophosphamide; vincristine; pathology; hodgkin disease; pediatric; carcinogenesis; radiation oncology; diagnosis; cancer classification; therapy; pediatrics; hodgkin lymphoma; nodular lymphocyte predominant hodgkin lymphoma; classical hodgkin lymphoma; tumor microenvironment; humans; human; article; collaborative care team; young adult oncology |
| Journal Title: | Seminars in Hematology |
| Volume: | 61 |
| Issue: | 4 |
| ISSN: | 0037-1963 |
| Publisher: | W.B. Saunders Co-Elsevier Inc. |
| Date Published: | 2024-08-01 |
| Start Page: | 245 |
| End Page: | 252 |
| Language: | English |
| DOI: | 10.1053/j.seminhematol.2024.05.003 |
| PUBMED: | 38851951 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
