Modulation of GITR for cancer immunotherapy Journal Article
| Authors: | Schaer, D. A.; Murphy, J. T.; Wolchok, J. D. |
| Article Title: | Modulation of GITR for cancer immunotherapy |
| Abstract: | Modulation of co-inhibitory and co-stimulatory receptors of the immune system has become a promising new approach for immunotherapy of cancer. With the recent FDA approval of CTLA-4 blockade serving as an important proof of principal, many new targets are now being translated into the clinic. Preclinical research has demonstrated that targeting glucocorticoid-induced tumor necrosis factor (TNF) receptor related gene (GITR), a member of TNF receptor superfamily, by agonist antibodies or natural ligand, can serve as an effective anti-tumor therapy. In this review, we will cover this research and the rationale that has led to initiation of two phase 1 clinical trials targeting GITR as a new immunotherapeutic approach for cancer. © 2011 Elsevier Ltd. |
| Keywords: | signal transduction; protein expression; unclassified drug; review; nonhuman; unspecified side effect; drug targeting; neoplasms; cd8+ t lymphocyte; animals; dendritic cell vaccine; cancer immunotherapy; melanoma; immune system; b lymphocyte; monoclonal antibody; sarcoma; regulatory t lymphocyte; immune response; immunotherapy; t-lymphocytes, regulatory; colon tumor; cd4+ t lymphocyte; lymphoma; natural killer cell; liver disease; dna vaccine; immunomodulation; immunostimulation; monocyte; up-regulation; macrophage; glucocorticoid induced tumor necrosis factor receptor; granulocyte; mast cell; eosinophil; basophil; monoclonal antibody 4-1bb; monoclonal antibody dta-1; monoclonal antibody ox-40; glucocorticoid-induced tnfr-related protein |
| Journal Title: | Current Opinion in Immunology |
| Volume: | 24 |
| Issue: | 2 |
| ISSN: | 0952-7915 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2012-04-01 |
| Start Page: | 217 |
| End Page: | 224 |
| Language: | English |
| DOI: | 10.1016/j.coi.2011.12.011 |
| PUBMED: | 22245556 |
| PROVIDER: | scopus |
| PMCID: | PMC3413251 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 24 August 2012" - "CODEN: COPIE" - "Source: Scopus" |
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